Products - Antigen detection - Stress diagnostics - Secretory IgA

Secretory IgA

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Disease information

Secretory IgA (sIgA) is produced in the mucous membranes and is the most dominant secretory immunoglobulin. It offers the first line of defense against pathogens that enter the body through different portals like oral cavity etc. It does not however activate the complement system and the defense takes place without an immune reaction.

Diagnostic Guidelines

The levels of sIgA are frequently used to assess the immune status of the mucosal membranes. Moreover, they are important indicators of stress. There is stress induced reduction in the levels of sIgA. However, this is independent of the subjective perception of stress. The titers are also not time bound, i.e., the reduction persists beyond the time a stressor affects an individual. They are thus used as indicators for prolonged periods of stress.

Some common conditions that cause a decrease in the levels of sIgA are:

  • Infections or diseases of the oral area
  • Immune diseases of the intestinal mucosa such as coeliac disease
  • Sjögren’s syndrome
  • Or different pharmacological interventions

Together with alpha amylase and cortisol, determination of sIgA titers allows for estimation of individual physiopathological effects of stress (stress reactivity).

Secretory IgA products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
632 ELISA cortisol
determination in saliva
antibody-coated
microplate wells
cortisol
633 ELISA sIgA
determination in saliva
antibody-coated
microplate wells
sIgA
634 ELISA alpha-amylase
determination in saliva
antibody-coated
microplate wells
alpha-amylase
Method Parameter Substrate Species/ Antigen
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