TSH, fT3, fT4 Products

Information

The hormones free triiodothyronine (fT3), free thyroxine (fT4), calcitonin and TSH (thyroid stimulating hormone,) are closely involved in the regulation of the human organism via the hypothalamus, pituitary gland and thyroid gland. The binding of TSH to the TSH receptors of the thyroid gland causes the synthesis and secretion of the T3 and T4 hormones. The largest proportion of circulating T3 and T4 is bound. Only free T3 and free T4 are biologically available.

Diagnostic Guidelines

In primary thyroid overfunction the thyroid gland produces too much T3 and T4, which inhibits the pituitary gland from releasing TSH. The TSH concentration in blood decreases; FT4 and FT3 are borderline high or increased. In secondary thyroid overfunction FT3 and FT4 are increased. The defect lies in the pituitary gland. It may release too much TSH– because of a TSH-producing tumour, which stimulates the thyroid gland to produce more T3 and T4. The cause may also be a thyroid hormone resistance. As well as being caused by disturbances in thyroid hormone regulation, the symptoms of a hyper- or hypothyroidism can also be the result of thyroiditis (inflammation of the thyroid gland).

Alongside the observation of the clinical disease signs, the determination of TSH, fT3 and fT4 concentrations is critical in the diagnostics of thyroid gland diseases.

For Research Use Only. Not For Use In Diagnostic Procedures.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.

Method:

Parameter:

Substrate:

Species/ Antigen:

wdt_ID	Method	Parameter	Substrate	Species/ Antigen
810	RIA	thyroglobulin (TG) coated tubes (CT); IRMA	antibody-coated tubes	native thyroglobulin
811	RIA	free triiodothyronine (FT3) coated tubes (CT)	antibody-coated tubes	triiodothyronine, human
812	ELISA	reverse triiodothyronine (RT3)	antibody-coated microplate wells
813	RIA	free thyroxine (FT4) coated tubes (CT)	antibody-coated tubes	thyroxine, human
814	RIA	Turbo thyrotropin (TSH) coated tubes (CT); IRMA	antibody-coated tubes	thyrotropin, human
815	RIA	calcitonin coated tubes (CT); IRMA	antibody-coated tubes	calcitonin, human
816	ELISA	calcitonin	antibody-coated microplate wells	synthetic human calcitonin
	Method	Parameter	Substrate	Species/ Antigen