Products - Autoimmune - Dermatology -
Autoimmune dermatoses are blister forming diseases of the skin and the associated mucous membranes. They involve formation of autoantibodies against the structural proteins in the skin; these proteins are responsible for cell to cell contacts and the overall integrity of both the epidermis and dermis of the skin. Objectively, we divide such diseases into four categories based on the location of the blisters and the target antigens involved. The types are as follows:
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wdt_ID | Method | Parameter | Substrate | Species/ Antigen |
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1 | IFA | AB adsorbent (dermatology IFA) |
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2 | ELISA | Dermatology Profile (BP180-NC16A-4X, BP230-CF, desmoglein 1, desmoglein 3, envoplakin, collagen type VII separately) |
antigen-coated microplate wells |
see individual ELISA |
3 | ELISA | envoplakin | antigen-coated microplate wells |
recombinant, expression in E. coli |
4 | IFA | antibodies against desmoglein 1 (pemphigus-associated) |
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5 | ELISA | desmoglein 1 | antigen-coated microplate wells |
recombinant, expression in mammalian cells, extracellular domain |
6 | IFA | desmoglein 1 desmoglein 3 |
transfected cells transfected cells control transfection (3 BIOCHIPs per field) |
EU 90 EU 90 EU 90 |
7 | IFA | antibodies against desmoglein 3 (pemphigus-associated) |
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8 | ELISA | desmoglein 3 | antigen-coated microplate wells |
recombinant, expression in mammalian cells, extracellular domain |
9 | IFA | antibodies against epidermis: desmosomes (pemphigus vulgaris control) |
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10 | IFA | Dermatology Screen (EM) EUROPattern epidermis: prickle cell desmosomes epidermal basement membrane |
oesophagus | monkey |
11 | IFA | epidermis: prickle cell desmosomes epidermal basement membrane |
oesophagus | monkey |
12 | IFA | Dermatology Screen 1 EUROPattern epidermis epidermis |
2 BIOCHIPs per field: oesophagus tongue |
monkey monkey |
13 | IFA | epidermis epidermis |
oesophagus tongue (2 BIOCHIPs per field) |
monkey monkey |
14 | IFA | Dermatology Mosaic 11 epidermis pemphigoid antigens transitional epithelium desmoglein 1 desmoglein 3 BP230gC BP180-NC16A-4X gliadin (GAF-3X) cell nuclei (ANA) endomysium |
11 BIOCHIPs per field: oesophagus salt-split skin bladder mucosa transfected cells transfected cells transfected cells control transfection BP180-NC16A-4X BIOCHIPs gliadin (GAF-3X) BIOCHIPs HEp-2 cells liver |
monkey monkey rat EU 90 EU 90 EU 90 EU 90 human monkey |
15 | IFA | Dermatology Mosaic 20 EUROPattern epidermis pemphigoid antigens |
2 BIOCHIPs per field: oesophagus salt-split skin |
monkey monkey |
16 | IFA | Dermatology Mosaic 20 epidermis pemphigoid antigens |
2 BIOCHIPs per field: oesophagus salt-split skin |
monkey monkey |
17 | IFA | Dermatology Mosaic 7 epidermis pemphigoid antigens BP230gC desmoglein 1 desmoglein 3 BP180-NC16A-4X |
6 BIOCHIPs per field: oesophagus salt-split skin transfected cells transfected cells transfected cells BP180-NC16A-4X BIOCHIPs |
monkey monkey EU 90 EU 90 EU 90 |
18 | IFA | antibodies against epidermis: basement membrane (bullous pemphigoid control) |
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19 | IFA | epidermis: prickle cell desmosomes epidermal basement membrane |
tongue | monkey |
20 | IFA | antibodies against BP230 (associated with bullous pemphigoid) |
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21 | ELISA | BP230-CF | antigen-coated microplate wells |
recombinant, expression in E. coli |
22 | IFA | antibodies against BP180 (associated with bullous pemphigoid) |
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23 | ELISA | BP180-NC16A-4X | antigen-coated microplate wells |
recombinant, expression in E. coli, tetramer of the NC16A domain |
24 | IFA | keratin (filaggrin, RA keratin) |
oesophagus | rat |
25 | IFA | transitional epithelium (detection of paraneoplastic pemphigus) |
bladder mucosa | rat |
2023 EUROIMMUN US