Products - Autoimmune - Gastroenterology - Chronic inflammatory bowel diseases

Chronic inflammatory bowel diseases

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Disease information

Chronic inflammatory bowel disease (CIBD) is divided into two main variants; Ulcerative colitis (UC) and Crohn’s disease (CD). The highlight however is that both share an autoimmune etiology and have genetic predispositions.

Ulcerative Colitis
Ulcerative colitis manifests as bloody diarrhea with left lower quadrant pain. It mainly affects the rectum and goes as proximal as caecum, resulting in a continuous lesion. It causes mucosal and submucosal ulcers and depending upon the extent of the intestine involved, increases risk for colonic cancer.

Crohn’s disease
Crohn’s disease can affect the alimentary tract anywhere from the oral cavity all the way down to the anus. The striking feature is that it results in skip lesions, i.e., few segments are involved and few aren’t (not a continuous disease). Keep watch over bloody diarrhea and right lower quadrant pain which are the primary symptoms of Crohn’s disease.

Diagnostic Guidelines

The investigation process carries differential and targeted diagnosis side by side. The high diagnostic requirements are met by IFA single assays as well as highly specific IFA mosaics (CIBD profiles) which have been developed for serological diagnosis of autoimmunological disease processes UC and CD.

Autoantibodies against the acinus cells of exocrine pancreas are a reliable marker for diagnosis of Crohn’s disease. They are highly specific and are frequently associated with the disease reflected by their high serum concentrations.

The fact that antigen in the pancreatic secretions namely CUZD1 and GP2 trigger CD, the presence of antibodies against these antigens namely rPAG1 against CUZD1 and PAG2 against GP2 propose another dimension for serological diagnosis of CD.

Other important markers for serological diagnosis:

  • ASCA (antibodies against Saccharomyces cerivisiae) for CD
  • Autoantibodies against intestinal goblet cells, for UC
  • Autoantibodies against DNA-bound lactoferrin, for UC

Chronic inflammatory bowel diseases products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
506 IFA antibodies against DNA-bound lactoferrin (pANCA)
(LFS ab control)
507 IFA DNA-bound lactoferrin (pANCA)
ANCA negative
LFS granulocytes
HSS granulocytes
(2 BIOCHIPs per field)

HSS granulocytes
(2 BIOCHIPs per field)
human
508 EUROLINE Autoimmune Gastrointestinal Diseases IgA
(tissue transglutaminase (endomysium), gliadin-analogue
fusion peptide (GAF-3X), mannan (ASCA))
EUROLINE
509 EUROLINE Autoimmune Gastrointestinal Diseases IgG
(tissue transglutaminase (endomysium),
gliadin-analogue fusion peptide (GAF-3X),
parietal cell antigen (PCA) separately
Intrinsic factor, mannan (ASCA))
EUROLINE
510 IFA intestinal goblet cells intestinal tissue monkey
511 IFA antibodies against intestinal goblet cells
(ulcerative colitis; UC IgA control)
512 IFA antibodies against intestinal goblet cells
(ulcerative colitis; UC IgG control)
513 IFA intestinal goblet cells goblet cells EU 80
514 IFA antibodies against pancreas acini
(CUZD1 control; associated with Crohn's disease)
515 IFA Crohn's Disease Mosaic 1
pancreas antigen rPAg1 (CUZD1)
pancreas antigen rPAg2 (GP2)
3 BIOCHIPs per field:
transfected cells
transfected cells
control transfection
EU 90
EU 90
EU 90
516 IFA Crohn's Disease Mosaic 2
pancreas ag rPAg1(CUZD1) / rPAg2(GP2)
2 BIOCHIPs per field:
transfected cells
control transfection
EU 90
EU 90
517 IFA CIBD Screen 3
pancreas ag rPAg1(CUZD1) / rPAg2(GP2)
intestinal goblet cells
3 BIOCHIPs per field:
transfected cells
goblet cells
control transfection
EU 90
EU 80
EU 90
518 IFA CIBD Profile 3
upper row:
pancreas ag rPAg1(CUZD1) / rPAg2(GP2)

intestinal goblet cells
pANCA
DNA-bound lactoferrin (pANCA)
ANCA negative
bottom row:
Saccharomyces cerevisiae
transfected cells
control transfection
goblet cells
granulocytes (EOH)
LFS granulocytes
HSS granulocytes
fungal smear
EU 90
EU 90
EU 80
human
human
human

S. cerevisiae
519 IFA CIBD Screen 6
pancreas ag rPAg1(CUZD1) / rPAg2(GP2)
intestinal goblet cells
Saccharomyces cerevisiae
cANCA, pANCA, GS-ANA
5 BIOCHIPs per field:
transfected cells
goblet cells
fungal smear
granulocytes (EOH)
control transfection
EU 90
EU 80
S. cerevisiae
human
EU 90
520 IFA CIBD Profile 7
upper row:
pancreas ag rPAg1(CUZD1) / rPAg2(GP2)
intestinal goblet cells
pANCA
bottom row:
Saccharomyces cerevisiae
transfected cells
goblet cells
granulocytes (EOH)
control transfection
fungal smear
EU 90
EU 80
human
EU 90
S. cerevisiae
521 IFA antibodies against pancreas secretion
(GP2 control; associated with Crohn's disease)
522 IFA antibodies against Saccharomyces cerevisiae
IgA positive control
fungal
smear
Saccharomyces
cerevisiae
523 IFA antibodies against Saccharomyces cerevisiae
IgG positive control
fungal
smear
Saccharomyces
cerevisiae
524 IFA Saccharomyces cerevisiae fungal
smear
Saccharomyces
cerevisiae
525 IFA Saccharomyces cerevisiae
negative control
526 ELISA Saccharomyces cerevisiae antigen-coated
microplate wells
mannan of
S. cerevisiae
527 ELISA MabTrack level adalimumab
528 ELISA MabTrack anti-drug antibody adalimumab
529 ELISA MabTrack level infliximab
530 ELISA MabTrack anti-drug antibody infliximab
Method Parameter Substrate Species/ Antigen
Contact our Autoimmune Product Team for further details and information

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