Chronic inflammatory bowel diseases Products

Disease information

Chronic inflammatory bowel disease (CIBD) is divided into two main variants; Ulcerative colitis (UC) and Crohn’s disease (CD). The highlight however is that both share an autoimmune etiology and have genetic predispositions.

Ulcerative Colitis
Ulcerative colitis manifests as bloody diarrhea with left lower quadrant pain. It mainly affects the rectum and goes as proximal as caecum, resulting in a continuous lesion. It causes mucosal and submucosal ulcers and depending upon the extent of the intestine involved, increases risk for colonic cancer.

Crohn’s disease
Crohn’s disease can affect the alimentary tract anywhere from the oral cavity all the way down to the anus. The striking feature is that it results in skip lesions, i.e., few segments are involved and few aren’t (not a continuous disease). Keep watch over bloody diarrhea and right lower quadrant pain which are the primary symptoms of Crohn’s disease.

Diagnostic Guidelines

The investigation process carries differential and targeted diagnosis side by side. The high diagnostic requirements are met by IFA single assays as well as highly specific IFA mosaics (CIBD profiles) which have been developed for serological diagnosis of autoimmunological disease processes UC and CD.

Autoantibodies against the acinus cells of exocrine pancreas are a reliable marker for diagnosis of Crohn’s disease. They are highly specific and are frequently associated with the disease reflected by their high serum concentrations.

The fact that antigen in the pancreatic secretions namely CUZD1 and GP2 trigger CD, the presence of antibodies against these antigens namely rPAG1 against CUZD1 and PAG2 against GP2 propose another dimension for serological diagnosis of CD.

Other important markers for serological diagnosis:

ASCA (antibodies against Saccharomyces cerivisiae) for CD
Autoantibodies against intestinal goblet cells, for UC
Autoantibodies against DNA-bound lactoferrin, for UC

Chronic inflammatory bowel diseases products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

Method:

Parameter:

Substrate:

Species/ Antigen:

wdt_ID	Method	Parameter	Substrate	Species/ Antigen
506	IFA	antibodies against DNA-bound lactoferrin (pANCA) (LFS ab control)
507	IFA	DNA-bound lactoferrin (pANCA) ANCA negative	LFS granulocytes HSS granulocytes (2 BIOCHIPs per field)	HSS granulocytes (2 BIOCHIPs per field) human
508	EUROLINE	Autoimmune Gastrointestinal Diseases IgA (tissue transglutaminase (endomysium), gliadin-analogue fusion peptide (GAF-3X), mannan (ASCA))	EUROLINE
509	EUROLINE	Autoimmune Gastrointestinal Diseases IgG (tissue transglutaminase (endomysium), gliadin-analogue fusion peptide (GAF-3X), parietal cell antigen (PCA) separately Intrinsic factor, mannan (ASCA))	EUROLINE
510	IFA	intestinal goblet cells	intestinal tissue	monkey
511	IFA	antibodies against intestinal goblet cells (ulcerative colitis; UC IgA control)
512	IFA	antibodies against intestinal goblet cells (ulcerative colitis; UC IgG control)
513	IFA	intestinal goblet cells	goblet cells	EU 80
514	IFA	antibodies against pancreas acini (CUZD1 control; associated with Crohn's disease)
515	IFA	Crohn's Disease Mosaic 1 pancreas antigen rPAg1 (CUZD1) pancreas antigen rPAg2 (GP2)	3 BIOCHIPs per field: transfected cells transfected cells control transfection	EU 90 EU 90 EU 90
516	IFA	Crohn's Disease Mosaic 2 pancreas ag rPAg1(CUZD1) / rPAg2(GP2)	2 BIOCHIPs per field: transfected cells control transfection	EU 90 EU 90
517	IFA	CIBD Screen 3 pancreas ag rPAg1(CUZD1) / rPAg2(GP2) intestinal goblet cells	3 BIOCHIPs per field: transfected cells goblet cells control transfection	EU 90 EU 80 EU 90
518	IFA	CIBD Profile 3 upper row: pancreas ag rPAg1(CUZD1) / rPAg2(GP2) intestinal goblet cells pANCA DNA-bound lactoferrin (pANCA) ANCA negative bottom row: Saccharomyces cerevisiae	transfected cells control transfection goblet cells granulocytes (EOH) LFS granulocytes HSS granulocytes fungal smear	EU 90 EU 90 EU 80 human human human S. cerevisiae
519	IFA	CIBD Screen 6 pancreas ag rPAg1(CUZD1) / rPAg2(GP2) intestinal goblet cells Saccharomyces cerevisiae cANCA, pANCA, GS-ANA	5 BIOCHIPs per field: transfected cells goblet cells fungal smear granulocytes (EOH) control transfection	EU 90 EU 80 S. cerevisiae human EU 90
520	IFA	CIBD Profile 7 upper row: pancreas ag rPAg1(CUZD1) / rPAg2(GP2) intestinal goblet cells pANCA bottom row: Saccharomyces cerevisiae	transfected cells goblet cells granulocytes (EOH) control transfection fungal smear	EU 90 EU 80 human EU 90 S. cerevisiae
521	IFA	antibodies against pancreas secretion (GP2 control; associated with Crohn's disease)
522	IFA	antibodies against Saccharomyces cerevisiae IgA positive control	fungal smear	Saccharomyces cerevisiae
523	IFA	antibodies against Saccharomyces cerevisiae IgG positive control	fungal smear	Saccharomyces cerevisiae
524	IFA	Saccharomyces cerevisiae	fungal smear	Saccharomyces cerevisiae
525	IFA	Saccharomyces cerevisiae negative control
526	ELISA	Saccharomyces cerevisiae	antigen-coated microplate wells	mannan of S. cerevisiae
527	ELISA	MabTrack level adalimumab
528	ELISA	MabTrack anti-drug antibody adalimumab
529	ELISA	MabTrack level infliximab
530	ELISA	MabTrack anti-drug antibody infliximab
	Method	Parameter	Substrate	Species/ Antigen

Chronic inflammatory bowel diseases

Disease information

Chronic inflammatory bowel diseases products

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