The evaluation of CSF is done to diagnose acute and chronic inflammatory disease processes of the central nervous systems. Acute CNS infections manifest as:
CSF infections can be caused by bacteria (such as Borrelia and Treponema pallidum), viruses (HSV, VZV, measles virus, EBV etc.) or parasites (such as Toxoplasma gondii). CSF analysis enables diagnosis of the infections. Moreover, it also allows for diagnosis of non-infectious diseases such as Multiple sclerosis (MS). The presence of intrathecal (within the CSF) antibodies is a specific indicator of MS.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.
wdt_ID | Method | Parameter | Substrate | Species/ Antigen |
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166 | ELISA | CSQ pair of controls anti-Treponema pallidum (IgG) |
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167 | ELISA | Treponema pallidum antibody determination in CSF |
antigen-coated microplate wells |
recombinant antigens 15 kDa, 17 kDa, 47 kDa, 42 kDa (TmpA) |
168 | EUROLINE | EUROLINE Borrelia-RN-AT (OspC Bg native, OspC Bb native, OspC Ba native, p39, VlsE Bb separately) |
EUROLINE | |
169 | EUROLINE | EUROLINE Borrelia-RN-AT (p18, p19, p20, p21, p58, OspC (p25), p39, p83, LBb, LBa, VlsE Bg, VlsE Bb, VlsE Ba separately) |
EUROLINE | |
170 | ELISA | Borrelia PLUS VlsE antibody determination in CSF |
antigen-coated microplate wells |
whole antigen, detergent extracts of Borrelia burgdorferi sensu stricto, Borrelia garinii and Borrelia afzelii PLUS recombinant VlsE from Borrelia burgdorferi sensu stricto |
171 | ELISA | Borrelia antibody determination in CSF |
antigen-coated microplate wells |
whole antigen, detergent extracts of Borrelia burgdorferi sensu stricto, Borrelia garinii and Borrelia afzelii |
172 | ELISA | CSQ pair of controls anti-Borrelia (IgG) |
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173 | ELISA | CSQ pair of controls anti-Borrelia (IgM) |
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174 | ELISA | CSQ pair of controls anti-Toxoplasma gondii (IgG) |
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175 | ELISA | Toxoplasma gondii antibody determination in CSF |
antigen-coated microplate wells |
native antigens of Toxoplasma gondii |
176 | ELISA | CSQ pair of controls anti-HSV-1/2 Pool (IgG) |
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177 | ELISA | Herpes simplex virus (HSV-1/2 Pool) antibody determination in CSF |
antigen-coated microplate wells |
native antigens from HSV-1 and HSV-2 |
178 | ELISA | CSQ pair of controls anti-Cytomegalovirus (IgG) |
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179 | ELISA | Cytomegalovirus (CMV) antibody determination in CSF |
antigen-coated microplate wells |
native antigens from CMV |
180 | ELISA | CSQ pair of controls anti-Rubella virus (IgG) |
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181 | ELISA | Rubella virus antibody determination in CSF |
antigen-coated microplate wells |
native antigens, strain "HPV-77" |
182 | ELISA | CSQ pair of controls anti-Measles virus (IgG) |
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183 | ELISA | Measles virus antibody determination in CSF |
antigen-coated microplate wells |
native antigens from Measles virus |
184 | ELISA | CSQ pair of controls anti-Mumps virus (IgG) |
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185 | ELISA | Mumps virus antibody determination in CSF |
antigen-coated microplate wells |
native antigens, strain "Enders" (ATCC VR-106) |
186 | ELISA | CSQ pair of controls anti-VZV (IgG) |
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187 | ELISA | CSQ pair of controls anti-TBE virus Vienna (IgG) |
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188 | ELISA | CSQ pair of controls anti-TBE virus (IgG) |
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189 | ELISA | CSQ pair of controls anti-TBE virus (IgM) |
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190 | ELISA | TBE virus antibody determination in CSF |
antigen-coated microplate wells |
TBE viral proteins (strain "K23") |
2023 EUROIMMUN US