Celiac disease

Diagnosis of CD relies on a combination of clinical assessment, biopsy, and serological detection of disease-specific autoantibodies.³ The American College of Gastroenterology recommends detection of tTG-IgA antibodies as the first-line test for suspected CD.³ Individuals should also be tested for total serum IgA, as IgA deficiency requires alternative testing using IgG-based assays such as DGP-IgG or tTG-IgG.³ While an intestinal biopsy is required to confirm the diagnosis in most cases, a non-biopsy strategy may be considered in select pediatrics when tTG-IgA levels exceed 10 times the upper limit of normal and a positive endomysial antibody IgA (EMA) test is confirmed on a second blood sample.³

Euroimmun offers a portfolio of serological assays to aid with celiac disease testing, including ELISAs for the detection of ttG and DGP antibodies of both IgA and IgG classes, as well as an immunofluorescence assay for the detection of EMA (IgA).