Biochemical analysis aligned with Endocrine Society guidelines¹˒²
For diagnosing primary aldosteronism and screening secondary hypertension
Biochemical analysis aligned with Endocrine Society guidelines¹˒²
For diagnosing primary aldosteronism and screening secondary hypertension
Demonstrated clinical application
Adult reference ranges and clinical cutoffs available for both supine and upright positions
Efficient workflow
ARR can be determined in a single plasma sample tube
Dual platform flexibility:
Both automated ChLIA and traditional ELISA options for varied throughput needs
Hypertension is a condition that affects 120 million individuals, accounting for nearly half of Americans. The condition is characterized by high blood pressure greater than 130/80 mmHg.3 Hypertension can be classified as primary (essential), in around 80% of hypertensive patients; and secondary, in around the remaining 20% of hypertensive patients.3 1 in 3 people worldwide will develop hypertension regardless of age and gender. The leading cause of secondary hypertension is the endocrine etiology, primary aldosteronism.1 In primary aldosteronism, excess aldosterone secretion by the adrenal gland suppresses renin levels within the Renin-Angiotensin-Aldosterone System (RAAS)—resulting in renal sodium retention, increase in volume, elevated blood pressure, and in more serious forms, hypokalemia.2 Patients with primary aldosteronism are at a higher risk of heart disease, stroke, renal disease and reduced psychological well-being compared to their essential hypertension counterparts.2 Consequently, assessment of the RAAS is essential for diagnostic and therapeutic purposes.4 Other common causes of secondary hypertension include obstructive sleep apnea, chronic kidney disease (CKD), drug or alcohol use, and renovascular hypertension.
Our endocrine hypertension portfolio can aid in the diagnosis of primary aldosteronism, the leading cause of secondary hypertension in the US.1,2 The plasma aldosterone/renin ratio (ARR) is used to detect possible cases of primary aldosteronism in patients with sustained high blood pressure—potassium is also assessed to aid in the accurate interpretation of aldosterone.1,2,5 Both aldosterone and renin should be measured to determine the ARR. Plasma aldosterone measurements are used in the diagnosis and treatment of primary aldosteronism, hypertension caused by primary aldosteronism, selective hyperaldosteronism, edematous states and other conditions of electrolyte balance.1,6 Plasma renin measurement is important in stratifying the diagnosis of the two most common forms of secondary hypertension which are primary aldosteronism and renovascular hypertension.1,3 Plasma renin evaluation can also help in selecting the most appropriate antihypertensive treatment.
References
For in vitro diagnostic use.
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