Factor V (Leiden) / factor II / MTHFR Direct

The EUROArray FV / FII+ / MTHFR Direct is specifically optimized for reliable determination of the most important genetic risk factors for thrombosis and is extremely easy to perform. The direct method enables the direct use of whole blood samples and eliminates the need for time and cost-intensive DNA isolation. The PCR primers and microarray probes are selected such that the mutations factor V Leiden (1691G>A), factor II (prothrombin) 20210G>A, MTHFR 677C>T and 1298A>C can be reliably detected. With the EUROArray FV / FII+ / MTHFR Direct, highest reliability of results is ensured also for rare genotypes. For this cause, the test system contains unique controls that show if there are further known mutations in the DNA in direct vicinity to the sequence variants which may interfere with the binding to the probes and thus affect the determination.

For the determination of the FV Leiden and the FII-20210G>A mutations and the polymorphisms 677C>T and 1298A>C in the MTHFR gene, different EUROArray test systems are available, so that the determination can be performed separately or in one test, according to the customer’s requirements.