Products - Antigen detection - Hyperaldosteronism - Plasma Renin Activity (PRA)

Plasma Renin Activity (PRA)

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Disease information

In 10 percent of the patients with high blood pressure and around 20 percent of the patients with therapy resistant hypertonia, the underlying cause is primary hyper-aldosteronism (PHA). It can be detected by estimation of serum aldosterone and renin levels. The ratio helps to differentiate it from secondary hyper-aldosteronism. Furthermore, it’s important to rule out another differential causing sodium retention and hypertension:

  • Adrenal hyperplasia or tumor of the glomerulosa cells (PHA): hypertension but with high aldosterone and low renin levels
  • Liddel syndrome (a hereditary disease caused by mutations in the epithelial sodium channel in renal tubules): hypertension but with low levels of both aldosterone and renin

Diagnostic Guidelines

Renin is estimated as enzymatic plasma renin activity (PRA). It is done in two steps: first the angiotensinogen (the substrate for renin) in the plasma is converted into angiotensin 1 in vitro. Then the angiotensin one is measured by an enzyme immunoassay.

  • Low sodium supply and physical activity
  • Pregnancy
  • Use of loop diuretics

Conditions associated with low renin levels:

  • Age
  • Impaired kidney function
  • Use of beta blockers

Plasma Renin Activity (PRA) products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
568 ELISA Plasma Renin Activity (PRA) antibody-coated
microplate wells
Method Parameter Substrate Species/ Antigen
Contact our Antigen Product Team for further details and information

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