CD163 is a membrane protein limited exclusively to the cells of immune system such as monocytes and macrophages. When these come into contact with a foreign stimulus e.g. bacterial molecules, the CD163 is enzymatically cleaved to soluble CD163 (sCD163). In glomerulonephritis, macrophages migrate into the tissue and release sCD163 into the urine. Thus, this marker can be measured in the urine for disease diagnosis.
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determination in urine