In routine practice, kidney function is assessed through non-specific organ markers such as serum creatinine and cystatin C. However, for valid estimation of glomerular function, the use of these parameters is significantly restricted. Early changes in renal function cannot be detected by these markers as serum creatinine levels show a reasonable hike only when glomerular function drops to 50 percent of the normal. Moreover, many factors such as sex, muscle mass and diet etc. can influence the levels of these markers.
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determination in serum