Uromodulin

Diagnostics for renal function use serum uromodulin levels. sUmod is a sensitive marker of kidney function and a strong indicator of early stage renal damage especially in patients for whom mainly the renal tubules have been damaged.
Serum uromodulin levels also allow identification of chronic kidney insufficiency. Drop in the levels are indicative of loss of renal integrity and progressive parenchymal damage. Moreover, the uromodulin levels also predict long term complications. Low levels are associated with increased total mortality, cardiovascular morbidity, cardiac insufficiency and progressive kidney insufficiency. Also, low levels after a renal transplant are indicative of functional loss of transplant.