Products - Antigen detection - Kidney marker - Uromodulin

Uromodulin

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Disease information

In routine practice, kidney function is assessed through non-specific organ markers such as serum creatinine and cystatin C. However, for valid estimation of glomerular function, the use of these parameters is significantly restricted. Early changes in renal function cannot be detected by these markers as serum creatinine levels show a reasonable hike only when glomerular function drops to 50 percent of the normal. Moreover, many factors such as sex, muscle mass and diet etc. can influence the levels of these markers.

Diagnostic Guidelines

Diagnostics for renal function use serum uromodulin levels. sUmod is a sensitive marker of kidney function and a strong indicator of early stage renal damage especially in patients for whom mainly the renal tubules have been damaged.
Serum uromodulin levels also allow identification of chronic kidney insufficiency. Drop in the levels are indicative of loss of renal integrity and progressive parenchymal damage. Moreover, the uromodulin levels also predict long term complications. Low levels are associated with increased total mortality, cardiovascular morbidity, cardiac insufficiency and progressive kidney insufficiency. Also, low levels after a renal transplant are indicative of functional loss of transplant.

Uromodulin products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Species/ Antigen
652 ELISA uromodulin
determination in serum
antibody-coated
microplate wells
Method Parameter Species/ Antigen
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