Dehydroepiandrosterone is produced in the zona reticularis of the adrenal cortex and is the most frequent steroid hormone in humans. It is released in the blood and then it travels to its target organs where it is converted into the androgens namely testosterone and dihydrotestosterone. Dehydroepiandrosterone (DHEA ) and dehydroepiandrosterone sulphate (DHEA-S) are thus considered a reservoir for formation of bioactive hormones in target organs.
The concentrations of these precursor hormones go up and down during the course of life of an individual. They are high in utero but decrease after birth. Then a second increase occurs with adrenarche, i.e., at the age of around 8 years. Thus these two hormones, DHEA and DHEA-S can are also used as biomarkers of adrenarche. They achieve their peak levels at about 20 years of age. However after that, they follow a slow and steady downward slope.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.
|811||ELISA||dehydroepiandrosterone sulfate (DHEA-S)||antibody-coated