Products - Antigen detection - Stress diagnostics - Cortisol

Cortisol

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Disease information

Identifying severe stress is an important basis for treating and preventing many diseases. The quantification of biological stress markers presents an efficient way to evaluate the effects of stressors, independent of their underlying cause. Here we talk about cortisol which is perhaps the most popular stress marker besides catecholamines.

Cortisol is produced in the cortex of the adrenal gland. Its production is induced by adrenocorticotropic hormone (ACTH) from the anterior pituitary, whose release is stimulated by corticotropin releasing hormone form the hypothalamus. The released cortisol then suppresses the release of ACTH through negative feedback. This entire series of regulatory influences is called the hypothalmic-pituitary axis.

Cortisol synthesis and release follows a circadian rhythm. It is highest during the first hour after one wakes up in the morning and the least during the early hours of night sleep. Once released into the blood, it is mainly bound to proteins. Only free cortisol (that is not bound to any proteins) is capable of diffusing into the saliva. This cortisol is biologically active and saliva makes a good medium for the determination of this biologically active form.

Diagnostic Guidelines

The levels of cortisol in saliva are a measure of the activity of hypothalamic-pituitary axis. They are increased in Cushing’s disease and decreased in Addison’s. Moreover, these levels are important predictors of the states of stress. In physical or mental stress, the levels increase. Whereas in states of chronic stress, the synthesis and release of cortisol cannot be maintained and hence, permanent drops are observed.

Estimation of free cortisol, in addition to secretory alpha amylase and IgA, enables evaluation of individual physiopathological effects of stress (stress reactivity).

Cortisol products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
629 ELISA cortisol
determination in saliva
antibody-coated
microplate wells
cortisol
630 ELISA sIgA
determination in saliva
antibody-coated
microplate wells
sIgA
631 ELISA alpha-amylase
determination in saliva
antibody-coated
microplate wells
alpha-amylase
Method Parameter Substrate Species/ Antigen
Contact our Antigen Product Team for further details and information

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