Endocrine Hypertension ChLIA

Information

Aldosterone is the chief mineralocorticoid that is produced in the adrenal cortex. Its function is to increase sodium levels in the blood. It does so primarily by increasing the retention of sodium through the epithelial sodium channel (along with excretion of potassium) in the kidneys.

40% of the adult population suffer from hypertension and in 10% of these patients it may be due to endocrine causes, such as Primary Aldosteronism (PA).  In another 5% of patients the elevated blood pressure is due to Renovascular Hypertension. ^{1 – 3,6} 

In PA excess, aldosterone levels may be produced due to an adenoma (Conn’s syndrome) or hyperplasia. Patients with this condition are at a stronger risk of heart disease and stroke than those with essential hypertension.⁴ PA patients also have higher cardiovascular morbidity and mortality than age and sex-matched patients with essential hypertension. 

Endocrine Hypertension products

For In Vitro Diagnostic Use

References

1. Kearney, PM et al. Lancet, 365 (9455): 217-223, 2005.
2. Rossi, GP et al. Crit Rev Clin Lab i, 44: 1-85, 2007.
3. Mulatero, P. et al. J Clin Endocrinol Metab, 89(3): 1045–1050, 2004.
4. Milliez, P. et al. J Am Coll Cardiol, 45 (8): 1243-8, 2005.
5. Funder, J.W. et al. J Clin Endocrinol Metab 93 (9): 3266-81, 2008.
6. Schilbach K, Junnila RK, Bidlingmaier M. Aldosterone to Renin Ratio as Screening Tool in Primary Aldosteronism. Exp Clin Endocrinol Diabetes. 2019 Feb;127(2-03):84-92.
7. Hartford M, Herlitz H, Perers E, Karlsson T, Herlitz J, Persson A, Caidahl K. Plasma renin activity has a complex prognostic role in patients with acute coronary syndromes. Int J Cardiol. 2021 Apr 15;329:198-204.