Plasma Renin Activity (PRA) Products

Information

In 10 percent of the patients with high blood pressure and around 20 percent of the patients with therapy resistant hypertonia, the underlying cause is primary hyper-aldosteronism (PHA). It can be detected by estimation of serum aldosterone and renin levels. The ratio helps to differentiate it from secondary hyper-aldosteronism. Furthermore, it’s important to rule out another differential causing sodium retention and hypertension:

Adrenal hyperplasia or tumor of the glomerulosa cells (PHA): hypertension but with high aldosterone and low renin levels
Liddel syndrome (a hereditary disease caused by mutations in the epithelial sodium channel in renal tubules): hypertension but with low levels of both aldosterone and renin

Diagnostic Guidelines

Renin is estimated as enzymatic plasma renin activity (PRA). It is done in two steps: first the angiotensinogen (the substrate for renin) in the plasma is converted into angiotensin 1 in vitro. Then the angiotensin one is measured by an enzyme immunoassay.

Low sodium supply and physical activity
Pregnancy
Use of loop diuretics

Conditions associated with low renin levels:

Age
Impaired kidney function
Use of beta blockers

Plasma Renin Activity (PRA) products

For Research Use Only. Not For Use In Diagnostic Procedures.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.

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