Infertility Products

Information

Infertility may be caused by antibodies against various tissues and cells that are essential for reproduction. In 20% of cases of immunologically mediated fertility disorders, anti-spermatozoa antibodies are detected (autoantibodies in men or alloantibodies in women). These antibodies primarily impair the mobility of the spermatozoa through surface binding and through agglutination processes.

Antibodies against ovarian antigens can be detected in women with primary ovarian insufficiency and after repeated in vitro fertilization. The autoantibodies are directed against various ovarian structures and inhibit the maturation of the egg and its interaction with spermatozoa. Target antigens are steroid-producing enzymes – especially in the theca interna cells – and the zona pellucida.

Diagnostic Guidelines

Unwanted childlessness is a growing problem with up to 20% of all couples in reproductive age are confronted temporarily or long-term.

The IIFT: Spermatozoa and the IIFT: Ovary can detect serum antibodies against spermatozoa and ovarian antigens, respectively, using indirect immunofluorescence. By using both tests, possible autoimmune-associated fertility disorders of both partners can be reliably identified.

For Research Use Only. Not For Use In Diagnostic Procedures.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.

Method:

Parameter:

Substrate:

Species/ Antigen:

wdt_ID	Method	Parameter	Substrate	Species/ Antigen
548	IFA	ovarian antigens	ovary	monkey
549	IFA	Infertility Mosaic 7 ovarian antigens Leydig cells placental antigens spermatozoa uterine antigens	ovarian antigens Leydig cells placental antigens spermatozoa uterine antigens 5 BIOCHIPs per field: ovary testis placenta smear uterus	monkey monkey monkey human monkey
550	IFA	antibodies against ovary: theca cells (ovary ab control)
551	IFA	Leydig cells	testis	monkey
552	IFA	antibodies against testis: Leydig cells (testis ab control)
553	IFA	antibodies against spermatozoa
554	IFA	spermatozoa	smear	human
	Method	Parameter	Substrate	Species/ Antigen