Products - Autoimmune - Endocrinology - Thyroid diseases

Thyroid diseases

Contact our Autoimmune Product Team for further details and information

Disease information

Autoimmune thyroid diseases are characterized by dysregulation of specific immune defenses (B and T cells) and production of antibodies which are predominantly of three types:

  • Thyroid peroxidase (TPO)
  • Thyroglobulin (TG)
  • TSH receptor (TR)

Grave’s disease is one of the most common autoimmune diseases in people and the most frequent cause of thyroid hyper-functioning. It can be recognized by a triad of symptoms called Merseburg triad which includes struma, exophthalmos and tachycardia. Another popular autoimmune thyroid disease is Hashimoto thyroiditis which involves progressive destruction of thyroid tissue by T-lymphocytes. So far, there is no absolute cure for Hashimoto thyroiditis. However, treatment aims at reverting the hypothyroid functioning caused by the disease.

Diagnostic Guidelines

Diagnosis of Grave’s disease is based on the detection of thyroid stimulating antibodies (TSH receptor). The prevalence is around 90 to 100 percent. Whereas in Hashimoto thyroiditis, the aim is to detect anti-TPO antibodies which have a prevalence of up to 90 percent whereas anti-TG antibodies occur in 60 to 70 percent of the cases.

Thyroid diseases products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
568 IFA thyroid gland
(MAb + TAb)
thyroid gland monkey
569 IFA thyroid gland (MAb + TAb)
mitochondria (AMA)
thyroid gland
kidney
(2 BIOCHIPs per field)
monkey
rat
570 IFA Polyendocrinopathy Mosaic
thyroid gland (MAb + TAb)
pancreas islets
adrenal cortex
ovarian antigens
Leydig cells
parietal cells (PCA)

thyroid gland (MAb + TAb)
pancreas islets
adrenal cortex
ovarian antigens
Leydig cells
parietal cells (PCA)
6 BIOCHIPs per field:
thyroid gland
pancreas
adrenal gland
ovary
testis
stomach
monkey
monkey
monkey
monkey
monkey
monkey
571 IFA EUROPLUS
thyroid gland (MAb + TAb)
thyroglobulin (TG)
2 BIOCHIPs per field:
thyroid gland
TG BIOCHIPs
monkey
human
572 IFA antibodies against thyroid microsomes
(MAb control)
573 ELISA thyroid peroxidase
(TPO)
antigen-coated
microplate wells
recombinant, expression with
Baculovirus vector in insect cells
574 RIA thyroid peroxidase (TPO)
coated tubes (CT)
antigen-coated
tubes
native thyroid
peroxidase, human
575 RIA thyroid peroxidase (TPO)
precipitation
labelled antigen native thyroid
peroxidase, human
576 RIA thyroid peroxidase (TPO)
magnetic separation
labelled antigen native thyroid
peroxidase, human
577 IFA antibodies against thyroglobulin
(TAb control)
578 ELISA thyroglobulin
(TG)
antigen-coated
microplate wells
native, human
thyroid gland
579 RIA thyroglobulin (TG)
coated tubes (CT); IRMA
antibody-coated
tubes
native
thyroglobulin
580 RIA thyroglobulin (TG)
coated tubes (CT)
antigen-coated
tubes
native thyroglobulin,
human
581 RIA thyroglobulin (TG)
magnetic separation
magnetic separation
labelled antigen
native thyroglobulin,
human
582 ELISA TSH receptor
(thyrotropin receptor)
antigen-coated
microplate wells
native,
porcine thyrocytes
583 ELISA TSH receptor
(thyrotropin receptor)
Fast ELISA
antigen-coated
microplate wells
native,
porcine thyrocytes
584 RIA TSH receptor
coated tubes (CT)
antigen-coated
tubes
native TSH receptor,
porcine
585 RIA free triiodothyronine (FT3)
coated tubes (CT)
antibody-coated
tubes
triiodothyronine,
human
586 ELISA reverse triiodothyronine (RT3) antibody-coated
microplate wells
587 RIA free thyroxine (FT4)
coated tubes (CT)
antibody-coated
tubes
thyroxine,
human
588 RIA Turbo thyrotropin (TSH)
coated tubes (CT); IRMA
antibody-coated
tubes
thyrotropin,
human
589 RIA alcitonin
coated tubes (CT); IRMA
antibody-coated
tubes
calcitonin,
human
590 ELISA calcitonin antibody-coated
microplate wells
synthetic human calcitonin
Method Parameter Substrate Species/ Antigen
For product information, please contact the EUROIMMUN Sales Team

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