Products - Autoimmune - Gastroenterology -
Autoimmune gastritis (AIG) is a disease in which autoantibodies attack the gastric mucosa, mainly the parietal cells in the fundus and body region of the stomach. For a quick review, the parietal cells produce hydrochloric acid and intrinsic factor, both highly crucial to gastric functions and heme synthesis. Destruction of parietal cells leads to achlorhydria and atrophy of the stomach mucosa. Moreover, a deficit in the intrinsic factor leads to pernicious anemia that develops over years during the course of the disease. Symptoms of pernicious anemia include:
Some other abnormalities you might stumble upon during the disease course include:
The individual product regulatory statements may vary, please refer to the instructions for use for more information.
wdt_ID | Method | Parameter | Substrate | Species/ Antigen |
---|---|---|---|---|
535 | IFA | Anti-Parietal cells (SM) IFA EUROPattern | stomach | monkey |
536 | IFA | parietal cells (PCA) |
stomach | monkey |
537 | EUROLINE | Autoimmune Gastrointestinal Diseases IgA (tissue transglutaminase (endomysium), gliadin-analogue fusion peptide (GAF-3X), mannan (ASCA)) |
EUROLINE | |
538 | EUROLINE | Autoimmune Gastrointestinal Diseases IgG (tissue transglutaminase (endomysium), gliadin-analogue fusion peptide (GAF-3X), parietal cell antigen (PCA) separately Intrinsic factor, mannan (ASCA)) |
EUROLINE | |
539 | IFA | parietal cells (PCA) mitochondria (AMA) |
stomach kidney (2 BIOCHIPs per field) |
monkey rat |
540 | IFA | antibodies against parietal cells (PCA control) |
||
541 | ELISA | parietal cells (PCA) |
antigen-coated microplate wells |
native, H+/K+ ATPase, porcine gastric mucosa |
542 | ELISA | ATP4B | antigen-coated microplate wells |
|
543 | IFA | intrinsic factor | intrinsic factor BIOCHIPs | |
544 | ELISA | intrinsic factor | antigen-coated microplate wells |
native, porcine gastric mucosa |
545 | IFA | EUROPLUS parietal cells (PCA) intrinsic factor |
2 BIOCHIPs per field: stomach intrinsic factor BIOCHIPs |
monkey |
546 | IFA | antibodies against parietal cells + intrinsic factor (PCA + intrinsic factor ab control) |
||
547 |
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