Products - Autoimmune - Gastroenterology - Coeliac disease

Coeliac disease

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Disease information

Celiac disease (also called gluten-sensitive enteropathy, GSE) is an autoimmune disease that primarily attacks the intestines and results in a wide variety of both gastroenterological and otherwise symptoms. The prevalence of the disease is estimated at to be 1%. Doctors argue it’s because most of the cases go undiagnosed as the symptoms are rather minimal or “atypical” in such instances.

Coeliac disease comes in with a broad spectrum of symptoms. One should always keep an eye on:

  • Chronic diarrhea
  • Vomiting and abdominal pain
  • Weight loss and anemia
  • Delayed puberty and osteoporosis (atypical symptoms)

Presence of eczema (dermatitis herpetiformis) in conjunction with abdominal disturbances also warrants a diagnostic roundup.

The disease process begins with the ingestion of gluten and overreaction of body’s immune system to it (in genetically predisposed individuals; those positive for HLA- DQ2 and DQ8). The pathogenic component of gluten, gliadin, is deamidated by tissue transglutaminase (tTG) in the enteric connective tissue. This deamidated gliadin is presented by the antigen presenting cells to lymphocytes. The result is B-lymphocytes activated and production of antibodies against deamidated gliadin peptides (DGP) and those against tTG. Moreover, T lymphocytes release inflammatory cytokines responsible for the overall inflammatory process.

Diagnostic Guidelines

According to guidelines by European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), patients displaying the relevant symptoms are investigated for many antibodies that are consistent with celiac disease. The antibodies that are implicated in the disease are as follows:

  • Anti-tTG antibodies
  • Total IgA antibodies
  • EmA (antibodies against endomysium)
  • Specific IgG-based tests such as those to detect antibodies against DGP

EmAs are very sensitive and specific markers to diagnose celiac disease. Their target antigen is tTG and they can be detected in sections of primate esophagus, liver and intestines.

Other important markers include anti-tTGs. These can be efficiently detected by ELISA or EUROLINE immunoblot. Of particular importance is the fact that most such patients are deficient in IgA. In all such patients, IgG (DGP) is considered for diagnosis of celiac disease.

Coeliac disease products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
478 EUROLINE Autoimmune Gastrointestinal Diseases IgA
(tissue transglutaminase (endomysium), gliadin-analogue
fusion peptide (GAF-3X), mannan (ASCA))
EUROLINE
479 EUROLINE Autoimmune Gastrointestinal Diseases IgG
(tissue transglutaminase (endomysium),
gliadin-analogue fusion peptide (GAF-3X),
parietal cell antigen (PCA) separately
Intrinsic factor, mannan (ASCA))
EUROLINE
480 IFA antibodies against endomysium
(EMA IgA control)
481 IFA antibodies against endomysium
(EMA IgG control)
482 ELISA tissue transglutaminase
(endomysium)
antigen-coated
microplate wells
recombinant,
expression with baculovirus vector
in insect cells
483 ELISA tissue transglutaminase
(endomysium)
antigen-coated
microplate wells
recombinant,
expression with baculovirus vector
in insect cells
484 EUROLINE Coeliac Disease Profile
(tissue transglutaminase (endomysium),
gliadin-analogue fusion peptide (GAF-3X) separately)
EUROLINE
485 IFA Coeliac Disease Screen (EM) EUROPattern
endomysium
oesophagus monkey
486 IFA endomysium oesophagus monkey
487 IFA EUROPLUS
endomysium
gliadin (GAF-3X)
2 BIOCHIPs per field:
oesophagus
gliadin (GAF-3X) BIOCHIPs
monkey
488 IFA Coeliac Disease Screen 9B
endomysium
tissue transglutaminase (tTG)
3 BIOCHIPs per field:
oesophagus
transfected cells
control transfection
monkey
EU 90
EU 90
489 IFA antibodies against endomysium plus gliadin (GAF-3X)
(EMA plus gliadin GAF-3X IgA control)
490 IFA antibodies against endomysium plus gliadin (GAF-3X)
(EMA plus gliadin GAF-3X IgG control)
491 IFA endomysium small intestine monkey
492 IFA EUROPLUS
endomysium
gliadin (GAF-3X)
2 BIOCHIPs per field:
small intestine
gliadin (GAF-3X) BIOCHIPs
monkey
493 IFA endomysium
endomysium
small intestine
oesophagus
(2 BIOCHIPs per field)
monkey
monkey
494 IFA EUROPLUS
endomysium
gliadin (GAF-3X)
endomysium
endomysium
4 BIOCHIPs per field:
small intestine
gliadin (GAF-3X) BIOCHIPs
oesophagus
liver
monkey
monkey
monkey
495 IFA endomysium
endomysium
endomysium
liver monkey
496 IFA endomysium liver monkey
497 IFA EUROPLUS
endomysium
gliadin (GAF-3X)
2 BIOCHIPs per field:
liver
gliadin (GAF-3X) BIOCHIPs
monkey
498 IFA endomysium
endomysium
liver
small intestine
(2 BIOCHIPs per field)
monkey
monkey
499 IFA EUROPLUS
endomysium
endomysium
gliadin (GAF-3X)
3 BIOCHIPs per field:
liver
small intestine
gliadin (GAF-3X) BIOCHIPs
monkey
monkey
500 IFA endomysium umbilical cord human
501 IFA antibodies against gliadin (GAF-3X)
(gliadin GAF-3X IgA control)
502 IFA antibodies against gliadin (GAF-3X)
(gliadin GAF-3X IgG control)
Method Parameter Substrate Species/ Antigen
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