Products - Autoimmune - Hepatology -
Primary Biliary Cholangitis (PBC) is an autoimmune disease that affects hepatic biliary tracts (outward passageways for bile). The obstruction leads to buildup of bile and other toxins causing cholestasis.
PBC shows predominance in females (>90%) with most of the cases occurring between the ages of 40 and 50. Its worldwide incidence is estimated at 4 to 31 cases per million of the population per year (indicative of its widespread occurrence).
The major histological changes seen in the disease revolve around lymphocellular infiltrate that affects small intra-hepatic bile ducts causing destruction and cholestasis. If you experience any of the following danger signs, it’s better to book yourself for a diagnostic workup :
The individual product regulatory statements may vary, please refer to the instructions for use for more information.
wdt_ID | Method | Parameter | Substrate | Species/ Antigen |
---|---|---|---|---|
393 | IFA | liver-specific antigens |
liver | monkey |
394 | EUROLINE | positive control serum: IgG, human, 100x concentrated for DL 1300-X G |
||
395 | EUROASSAY | AMA M2, LKM-1, SLA/LP | EUROASSAY strip with antigens |
|
396 | IFA | Liver Mosaic 1 liver-kidney microsomes (LKM), ANA mitochondria (AMA), LKM |
2 BIOCHIPs per field: liver kidney |
rat rat |
397 | IFA | Liver Mosaic 2 liver antigens, cell nuclei (ANA) AMA M7, heart antigens cell nuclei (ANA) LKM, ANA mitochondria (AMA), LKM smooth muscles (ASMA) |
6 BIOCHIPs per field: liver heart HEp-2 cells liver kidney stomach |
monkey monkey human rat rat rat |
398 | EUROLINE | Liver Profile 2 (AMA M2, M2-3E, LKM-1, LC-1, SLA/LP separately) |
EUROLINE | |
399 | EUROASSAY | LKM-1, LC-1, SLA/LP | EUROASSAY strip with antigens |
|
400 | IFA | Liver Sreen 1 mitochondria (AMA), LKM soluble liver antigen/ liver-pancreas antigen (SLA/LP) LKM, ANA smooth muscles (ASMA) |
4 BIOCHIPs per field: kidney transfected cells liver stomach |
rat EU 90 rat rat |
401 | IFA | Liver Mosaic 3 liver antigens, cell nuclei (ANA) skeletal muscle cell nuclei (ANA) LKM, cell nuclei (ANA) mitochondria (AMA), LKM smooth muscles (ASMA) |
6 BIOCHIPs per field: liver musculus iliopsoas HEp-2 cells liver kidney stomach |
monkey monkey human rat rat rat |
402 | EUROLINE | Liver Profile (AMA M2, LKM-1, LC-1, SLA/LP separately) |
EUROLINE | |
403 | EUROASSAY | Liver Profile AMA M2, LKM-1, LC-1, SLA/LP |
EUROASSAY strip with antigens |
|
404 | EUROLINE | Autoimmune Liver Diseases (AMA M2, M2-3E, Sp100, PML, gp210, LKM-1, LC-1, SLA/LP, Ro-52 separately) |
EUROLINE | |
405 | EUROLINE | Autoimmune Liver Diseases 14 Ag (AMA-M2, M2-3E, Sp100, PML, gp210, LKM-1, LC-1, SLA/LP, SS-A, Ro-52, Scl-70, CENP A, CENP B, PGDH separately) |
EUROLINE | |
406 | IFA | Autoimmune liver diseases Screen 8 EUROPattern liver antigens, cell nuclei (ANA) F-actin cell nuclei (ANA), EUROPattern LKM, ANA mitochondria (AMA), LKM smooth muscles (ASMA) |
6 BIOCHIPs per field: liver VSM47 HEp-2 cells liver kidney stomach |
monkey rat human rat rat rat |
407 | IFA | Liver Mosaic 8 liver antigens, cell nuclei (ANA) F-actin cell nuclei (ANA) LKM, ANA mitochondria (AMA), LKM smooth muscles (ASMA) |
6 BIOCHIPs per field: liver VSM47 HEp-2 cells liver kidney stomach |
monkey rat human rat rat rat |
408 | IFA | Autoimmune liver diseases Screen 9 EUROPattern mitochondria (AMA), LKM LKM, ANA smooth muscles (ASMA) F-actin |
4 BIOCHIPs per field: kidney liver stomach VSM47 |
rat rat rat rat |
409 | IFA | Liver Mosaic 9 mitochondria (AMA), LKM LKM, ANA smooth muscles (ASMA) F-actin |
4 BIOCHIPs per field: kidney liver stomach VSM47 |
rat rat rat rat |
410 | IFA | antibodies against Sp100 (nuclear granula, nuclear dots; associated with PBC) |
||
411 | IFA | antibodies against nuclear membrane | ||
412 | IFA | mitochondria (AMA) | kidney | rat |
413 | IFA | test performance control (AMA, IgG) |
||
414 | IFA | AMA/ASMA IFA (KR/SR) EUROPattern mitochondria (AMA) smooth muscles (ASMA) |
2 BIOCHIPs per field: kidney stomach |
rat rat |
415 | IFA | mitochondria (AMA) smooth muscles (ASMA) |
kidney stomach (2 BIOCHIPs per field) |
rat rat |
416 | EUROASSAY | AMA Profile (AMA M2, M4, M9 separately) |
EUROASSAY strip with antigens |
|
417 | IFA | mitochondria (AMA) smooth muscles (ASMA) |
kidney stomach (2 BIOCHIPs per field) |
mouse mouse |
2023 EUROIMMUN US