Products - Autoimmune - Nephrology - Goodpasture’s syndrome

Goodpasture's syndrome

Contact our Autoimmune Product Team for further details and information

Disease information

Goodpasture syndrome also called pulmonary renal syndrome, is a disease of autoimmune etiology whereby special antibodies are formed against the alveolar (lung) and glomerular (kidney) basement membranes. Talking strictly about kidneys, this disease causes rapidly progressive glomerulonephritis characterized by rapidly declining kidney functions. Goodpasture syndrome affects men six times more than women, especially those in the younger segment of the population curve and is clinically detected by a combination of renal and pulmonary symptoms.

Diagnostic Guidelines

The primary target of the anti-GBM antibodies is the alpha-3 chain of type 4 collagen in the glomerular basement membranes. These antibodies are mostly of IgG class and can be detected qualitatively and quantitatively through IFA and quantitatively through ELISA. High titers hold a high predictive value and are positive in 60 percent of the patients with the disease limited to only kidneys and 90% of the patients with lung involvement too.

Of special importance is the association of the disease with ANCA (>35%). Hence individuals positive for serum ANCA should also be tested for anti-GBM antibodies to diagnose Goodpasture syndrome in the bud, if any.

Goodpasture's syndrome products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
1 EUROLINE myeloperoxidase (MPO)
proteinase 3 (PR3)
glomerular basement membrane (GBM)
EUROLINE
2 IFA renal glomeruli (GBM)
and renal tubuli
kidney monkey
3 IFA EUROPLUS
kidney glomeruli and tubuli
glomerular basement membrane (GBM)
2 BIOCHIPs per field:
kidney
GBM BIOCHIPs
monkey
4 ELISA glomerular basement membrane
(GBM)
antigen-coated
microplate wells
alpha-3 chain of type IV collagen,
incl. NC1 domain, from bovine kidney
5 IFA lung alveoli lung monkey
6 IFA renal glomeruli (GBM)
lung alveoli
(Goodpasture syndrome)
kidney
lung
(2 BIOCHIPs per field)
monkey
monkey
7
Method Parameter Substrate Species/ Antigen
Contact our Autoimmune Product Team for further details and information

Product Catalog

Download our full EUROIMMUN US 2022 Product Catalog (PDF 12MB)

Download EUROIMMUN US 2022 Product Catalog (PDF)

2022 EUROIMMUN US

Privacy Policy | Sitemap