Products - Autoimmune - Neurology -
Autoimmune encephalitis, as the name indicates, is an immune disease directed against neuronal cell surface antigens. Most of the antibodies are directed against glutamate receptors (both type NMDA and AMPA), GABAB receptors, voltage gated potassium channels and associated proteins (LGI1, CASPR2, TAG1/Contactin-2). Since these antigens are involved in synaptic transmission in one way or the other, autoimmunity against them breeds seizures and neuropsychiatric manifestations. The resulting conditions include:
All these syndromes are potentially lethal and they may be associated with a variety of para and non-paraneoplastic syndromes. 10 to 70 percent cases have an underlying tumor. The determination is based on the type of antibody present. Anyhow, since appropriate therapies are available including both immunotherapies and tumor resection procedures, and they result in significant regression in the symptoms, an early diagnosis is the key to a favorable prognosis.
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| wdt_ID | Method | Parameter | Substrate | Species/ Antigen |
|---|---|---|---|---|
| 649 | IFA | antibodies against glutamate receptor (type NMDA) | ||
| 650 | IFA | Autoimmune Encephalitis Mosaic 1 glutamate receptor (type NMDA) glutamate receptor (type AMPA1) glutamate receptor (type AMPA2) contactin-associated protein 2 (CASPR2) leucine-rich glioma-inactivated protein 1 (LGI1) GABA B receptor |
6 BIOCHIPs per field: transfected cells transfected cells transfected cells transfected cells transfected cells transfected cells |
EU 90 EU 90 EU 90 EU 90 EU 90 EU 90 |
| 651 | IFA | RC-IFA Neurology Mosaic 14A glutamate receptor (type NMDA) contactin-associated protein 2 (CASPR2) IgLON family member 5 (IgLON5) dipeptidyl aminopeptidase-like protein 6 (DPPX) leucine-rich glioma-inactivated protein 1 (LGI1) |
6 BIOCHIPs per field: transfected cells transfected cells transfected cells transfected cells transfected cells transfected cells |
EU 90 EU 90 EU 90 EU 90 EU 90 EU 90 |
| 652 | IFA | glutamate receptor (type NMDA) | transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
| 653 | IFA | glutamate receptor (type NMDA) EUROPattern | transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
| 655 | IFA | Autoimmune Encephalitis Mosaic 6 EUROPattern glutamate receptor (type NMDA) contactin-associated protein 2 (CASPR2) glutamate receptors (type AMPA1/2) leucine-rich glioma-inactivated protein 1 (LGI1) |
6 BIOCHIPs per field: transfected cells transfected cells transfected cells transfected cells transfected cells transfected cells |
EU 90 EU 90 EU 90 EU 90 EU 90 EU 90 |
| 658 | IFA | Autoimmune Encephalitis Mosaic 6 glutamate receptor (type NMDA) contactin-associated protein 2 (CASPR2) glutamate receptors (type AMPA1/2) leucine-rich glioma-inactivated protein 1 (LGI1) dipeptidyl aminopeptidase-like protein 6 (DPPX) GABA B receptor | 6 BIOCHIPs per field: transfected cells transfected cells transfected cells transfected cells transfected cells transfected cells |
EU 90 EU 90 EU 90 EU 90 EU 90 EU 90 |
| 666 | IFA | Autoimmune Encephalitis Mosaic 6 glutamate receptor (type NMDA) contactin-associated protein 2 (CASPR2) glutamate receptors (type AMPA1/2) leucine-rich glioma-inactivated protein 1 (LGI1) dipeptidyl aminopeptidase-like protein 6 (DPPX) GABA B receptor | 6 BIOCHIPs per field: transfected cells transfected cells transfected cells transfected cells transfected cells transfected cells | EU 90 EU 90 EU 90 EU 90 EU 90 EU 90 |
| 667 | IFA | glutamate receptor (type AMPA1) glutamate receptor (type AMPA2) |
glutamate receptor (type AMPA2) transfected cells transfected cells control transfection (3 BIOCHIPs per field) |
EU 90 EU 90 EU 90 |
| 668 | IFA | antibodies against GABA B receptor | ||
| 669 | IFA | GABA B receptor | transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
| 670 | IFA | GABA B receptor EUROPattern | transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
| 671 | IFA | antibodies against dipeptidyl aminopeptidase-like protein 6 (DPPX ab control) |
||
| 672 | IFA | dipeptidyl aminopeptidase-like protein 6 (DPPX) |
transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
| 673 | IFA | dipeptidyl aminopeptidase-like protein 6 (DPPX) EUROPattern |
transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
| 674 | IFA | antibodies against IgLON family member 5 (IgLON5) | ||
| 675 | IFA | IgLON family member 5 (IgLON5) | transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
| 676 | IFA | Anti-VGKC-Ass. Proteins Mosaic 1 EUROPattern leucine-rich glioma-inact. prot. 1 (LGI1) contactin-associated protein 2 (CASPR2) |
3 BIOCHIPs per field: transfected cells transfected cells control transfection |
EU 90 EU 90 EU 90 |
| 677 | IFA | Anti-VGKC-Ass. Proteins Mosaic 1 leucine-rich glioma-inact. prot. 1 (LGI1) contactin-associated protein 2 (CASPR2) |
3 BIOCHIPs per field: transfected cells transfected cells control transfection |
EU 90 EU 90 EU 90 |
| 678 | IFA | antibodies against leucine-rich glioma-inactivated protein 1 (LGI1 ab control) |
||
| 679 | IFA | antibodies against contactin-associated protein 2 (CASPR2 ab control) |
||
| 680 | IFA | contactin-associated protein 2 (CASPR2) | transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
| 681 | IFA | leucine-rich glioma-inactivated protein 1 (LGI1) | transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
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