Products - Autoimmune - Neurology - Autoimmune encephalitis

Autoimmune encephalitis

Contact our Autoimmune Product Team for further details and information

Disease information

Autoimmune encephalitis, as the name indicates, is an immune disease directed against neuronal cell surface antigens. Most of the antibodies are directed against glutamate receptors (both type NMDA and AMPA), GABAB receptors, voltage gated potassium channels and associated proteins (LGI1, CASPR2, TAG1/Contactin-2). Since these antigens are involved in synaptic transmission in one way or the other, autoimmunity against them breeds seizures and neuropsychiatric manifestations. The resulting conditions include:

  • Autoimmune limbic encepthalitis
  • Neuromyotonia
  • Morvan’s syndrome

All these syndromes are potentially lethal and they may be associated with a variety of para and non-paraneoplastic syndromes. 10 to 70 percent cases have an underlying tumor. The determination is based on the type of antibody present. Anyhow, since appropriate therapies are available including both immunotherapies and tumor resection procedures, and they result in significant regression in the symptoms, an early diagnosis is the key to a favorable prognosis.

Diagnostic Guidelines

The diagnosis of autoimmune encephalitis is made on a combination of clinical picture and supportive findings like brain MRT, EEG, CSF analysis and serological test for determination of antibodies. Monospecific assays for determination of serum antibody levels are by far the best methods for disease diagnosis. However, they are combined with a variety of conventional immunohistochemical detection procedures.

The overall diagnostic aim is also to rule out differentials such as infectious encephalitis (especially HSV) and other similar conditions of the central and peripheral nervous systems. One should keep in mind the possibility of overlap of syndromes. Hence, if a patient turns out positive for antibodies on serology, we also recommend comprehensive tumor investigations.

Autoimmune encephalitis products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
649 IFA antibodies against glutamate receptor (type NMDA)
650 IFA Autoimmune Encephalitis Mosaic 1
glutamate receptor (type NMDA)
glutamate receptor (type AMPA1)
glutamate receptor (type AMPA2)
contactin-associated protein 2 (CASPR2)
leucine-rich glioma-inactivated protein 1 (LGI1)
GABA B receptor
6 BIOCHIPs per field:
transfected cells
transfected cells
transfected cells
transfected cells
transfected cells
transfected cells
EU 90
EU 90
EU 90
EU 90
EU 90
EU 90
651 IFA RC-IFA Neurology Mosaic 14A
glutamate receptor (type NMDA)
contactin-associated protein 2 (CASPR2)
IgLON family member 5 (IgLON5)
dipeptidyl aminopeptidase-like protein 6 (DPPX)
leucine-rich glioma-inactivated protein 1 (LGI1)
6 BIOCHIPs per field:
transfected cells
transfected cells
transfected cells
transfected cells
transfected cells
transfected cells
EU 90
EU 90
EU 90
EU 90
EU 90
EU 90
652 IFA glutamate receptor (type NMDA) transfected cells
control transfection
(2 BIOCHIPs per field)
EU 90
EU 90
653 IFA glutamate receptor (type NMDA) EUROPattern transfected cells
control transfection
(2 BIOCHIPs per field)
EU 90
EU 90
655 IFA Autoimmune Encephalitis Mosaic 6 EUROPattern
glutamate receptor (type NMDA)
contactin-associated protein 2 (CASPR2)
glutamate receptors (type AMPA1/2)
leucine-rich glioma-inactivated protein 1 (LGI1)
6 BIOCHIPs per field:
transfected cells
transfected cells
transfected cells
transfected cells
transfected cells
transfected cells
EU 90
EU 90
EU 90
EU 90
EU 90
EU 90
658 IFA Autoimmune Encephalitis Mosaic 6 glutamate receptor (type NMDA) contactin-associated protein 2 (CASPR2) glutamate receptors (type AMPA1/2) leucine-rich glioma-inactivated protein 1 (LGI1) dipeptidyl aminopeptidase-like protein 6 (DPPX) GABA B receptor 6 BIOCHIPs per field:
transfected cells
transfected cells
transfected cells
transfected cells
transfected cells
transfected cells
EU 90
EU 90
EU 90
EU 90
EU 90
EU 90
666 IFA Autoimmune Encephalitis Mosaic 6 glutamate receptor (type NMDA) contactin-associated protein 2 (CASPR2) glutamate receptors (type AMPA1/2) leucine-rich glioma-inactivated protein 1 (LGI1) dipeptidyl aminopeptidase-like protein 6 (DPPX) GABA B receptor 6 BIOCHIPs per field: transfected cells transfected cells transfected cells transfected cells transfected cells transfected cells EU 90 EU 90 EU 90 EU 90 EU 90 EU 90
667 IFA glutamate receptor (type AMPA1)
glutamate receptor (type AMPA2)
glutamate receptor (type AMPA2)
transfected cells
transfected cells
control transfection
(3 BIOCHIPs per field)
EU 90
EU 90
EU 90
668 IFA antibodies against GABA B receptor
669 IFA GABA B receptor transfected cells
control transfection
(2 BIOCHIPs per field)
EU 90
EU 90
670 IFA GABA B receptor EUROPattern transfected cells
control transfection
(2 BIOCHIPs per field)
EU 90
EU 90
671 IFA antibodies against dipeptidyl aminopeptidase-like protein 6
(DPPX ab control)
672 IFA dipeptidyl aminopeptidase-like protein 6
(DPPX)
transfected cells
control transfection
(2 BIOCHIPs per field)
EU 90
EU 90
673 IFA dipeptidyl aminopeptidase-like protein 6
(DPPX) EUROPattern
transfected cells
control transfection
(2 BIOCHIPs per field)
EU 90
EU 90
674 IFA antibodies against IgLON family member 5 (IgLON5)
675 IFA IgLON family member 5 (IgLON5) transfected cells
control transfection
(2 BIOCHIPs per field)
EU 90
EU 90
676 IFA Anti-VGKC-Ass. Proteins Mosaic 1 EUROPattern
leucine-rich glioma-inact. prot. 1 (LGI1)
contactin-associated protein 2 (CASPR2)
3 BIOCHIPs per field:
transfected cells
transfected cells
control transfection
EU 90
EU 90
EU 90
677 IFA Anti-VGKC-Ass. Proteins Mosaic 1
leucine-rich glioma-inact. prot. 1 (LGI1)
contactin-associated protein 2 (CASPR2)
3 BIOCHIPs per field:
transfected cells
transfected cells
control transfection
EU 90
EU 90
EU 90
678 IFA antibodies against leucine-rich glioma-inactivated protein 1
(LGI1 ab control)
679 IFA antibodies against contactin-associated protein 2
(CASPR2 ab control)
680 IFA contactin-associated protein 2 (CASPR2) transfected cells
control transfection
(2 BIOCHIPs per field)
EU 90
EU 90
681 IFA leucine-rich glioma-inactivated protein 1 (LGI1) transfected cells
control transfection
(2 BIOCHIPs per field)
EU 90
EU 90
Method Parameter Substrate Species/ Antigen
Contact our Autoimmune Product Team for further details and information

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