Products - Autoimmune - Neurology -
Paraneoplastic neurological syndromes (PNS) are diseases of the nervous system, both central and peripheral, that occur in relation to a developing tumor. However, they are not a direct product of the tumor or are caused by its metastasis. Instead, they bud from the antigens expressed by the tumor which then induce the formation of autoantibodies. Most malignant diseases (around 15%) especially a lung tumor, come with paraneoplastic neurological syndrome (PNS).
Tumor cells express a variety of antigens. These include:
These antigens induce the formation of autoantibodies. Consequently, the antibodies then localize themselves to these antigens in the nervous tissue and cause neurological manifestations.
Two types of nomenclature are used to express the PNS-specific antibodies. One gets its basis from the first two letters of the patient’s name (such as Yo for Young and Ma for Margaret). The other stems from the immunohistochemical staining properties of the antibodies. We, however use the former since it’s independent of the test procedure.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.
| wdt_ID | Method | Parameter | Substrate | Species/ Antigen |
|---|---|---|---|---|
| 626 | IFA | brain: grey and white matter, Purkinje cell cytoplasm (Yo), Hu and Ri antigen CV2, Ma, amphiphysin |
cerebellum | monkey |
| 627 | EUROLINE | positive control serum: IgG, human, 100x concentrated for DL 1111-1 G, DL 1111-2 G, DL 1111-4 G and DL 1111-7 G |
||
| 628 | IFA | Neurology Mosaic 1 EUROPattern Yo, Hu, Ri, CV2, Ma, amphiphysin medullated nerves non-medullated nerves |
3 BIOCHIPs per field: cerebellum nerves intestinal tissue |
monkey monkey monkey |
| 629 | IFA | Neurology Mosaic 1 Yo, Hu, Ri, CV2, Ma, amphiphysin medullated nerves non-medullated nerves |
3 BIOCHIPs per field: cerebellum nerves intestinal tissue |
monkey monkey monkey |
| 630 | IFA | Neurology Mosaic14 cerebellum antigens non-medullated nerves |
2 BIOCHIPs per field: cerebellum non-medullated nerves |
monkey monkey |
| 631 | IFA | Yo, Hu, Ri, CV2, Ma, amphiphysin medullated nerves non-medullated nerves cell nuclei (ANA) |
cerebellum nerves intestinal tissue HEp-2 cells (4 BIOCHIPs per field) |
monkey monkey monkey human |
| 632 | IFA | Neurology Mosaic 17 Yo, Hu, Ri, CV2, Ma, amphiphysin, NMO cerebrum antigens, NMO NMO, optic nerve antigens aquaporin-4 |
5 BIOCHIPs per field cerebellum cerebrum optic nerve transfected cells control transfection |
monkey monkey monkey EU 90 EU 90 |
| 633 | IFA | Neurology Mosaic 2 Yo, Hu, Ri, CV2, Ma, amphiphysin medullated nerves |
2 BIOCHIPs per field: cerebellum nerves |
monkey monkey |
| 634 | EUROLINE | Neuronal Antigens Profile 2 (amphiphysin, CV2, PNMA2 (Ma-2/Ta), Ri, Yo, Hu separately) |
EUROLINE | |
| 635 | EUROLINE | Neuronal Antigens Profile PLUS RST (amphiphysin, CV2, PNMA2 (Ma-2/Ta), Ri, Yo, Hu, recoverin, SOX1, titin separately) |
EUROLINE | |
| 636 | EUROLINE | Neuronal Antigens Profile SOX1, titin |
EUROLINE | |
| 638 | EUROLINE | positive control serum: IgG, human, 100x concentrated for DL 1111-6 G |
||
| 639 | EUROLINE | Paraneoplastic Neurologic Syndromes - 12 Ag (amphiphysin, CV2, PNMA2 (Ma-2/Ta), Ri, Yo, Hu, recoverin, SOX1, titin, Zic4, GAD65, Tr (DNER) separately) |
EUROLINE | |
| 640 | IFA | Neurology Mosaic 8 EUROPattern Yo, Hu, Ri, CV2, Ma, amphiphysin medullated nerves non-medullated nerves pancreas islets |
4 BIOCHIPs per field: cerebellum nerves intestinal tissue pancreas |
monkey monkey monkey monkey |
| 641 | IFA | Neurology Mosaic 8 Yo, Hu, Ri, CV2, Ma, amphiphysin medullated nerves non-medullated nerves pancreas islets |
4 BIOCHIPs per field cerebellum nerves intestinal tissue pancreas |
monkey monkey monkey monkey |
| 642 | IFA | antibodies against Delta and Notch-like epidermal growth factor-related receptor (DNER CBA control) |
||
| 643 | IFA | Delta and Notch-like epidermal growth factor-related receptor (DNER) |
transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
| 644 | IFA | antibodies against Purkinje cell cytoplasm (Yo ab control) |
||
| 645 | IFA | Purkinje Cell Mosaic 1 Yo/CDR2 DNER ITPR1 CARP |
4 BIOCHIPs per field: transfected cells transfected cells transfected cells transfected cells |
EU 90 EU 90 EU 90 EU 90 |
| 646 | IFA | antibodies against neuronal nuclei: Ri antigen (Ri ab control) |
||
| 647 | IFA | antibodies against neuronal nuclei: Hu antigen (Hu ab control) |
||
| 648 | IFA | zinc finger protein ZIC4 | transfected cells control transfection (2 BIOCHIPs per field) |
EU 90 EU 90 |
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