Products - Autoimmune - Rheumatology -
Systemic lupus erythematous is an autoimmune disease belonging to the collagenosis group. It is characterized by antibodies against a multitude of body’s organs and organ systems. These antibodies are primarily directed against double stranded DNA (dsDNA). 60 to 80% of the cases of systemic lupus erythematous are positive for these antibodies. However, anti-dsDNA antibodies are also found in association with some other conditions such as autoimmune hepatitis and even in some healthy persons. Anyhow, around 85 percent of the people with these antibodies eventually develop systemic lupus erythematous.
Patients with SLE also tend to have antibodies against nucleosomes which are an exclusive marker for the disease. However, the detection of these requires advanced testing systems and antigens that are free of histone H1, Scl 70 and other non-histone proteins.
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wdt_ID | Method | Parameter | Substrate | Species/ Antigen |
---|---|---|---|---|
284 | IFA | cell nuclei (ANA) EUROPattern cell nuclei (ANA) |
HEp-2 cells liver (2 BIOCHIPs per field) |
human monkey |
285 | IFA | cell nuclei (ANA global test) |
HEp-2 cells liver (2 BIOCHIPs per field) |
human monkey |
286 | IFA | EUROPLUS ANA Mosaic 10 cell nuclei (ANA) SS-A + SS-B |
2 BIOCHIPs per field: HEp-2 cells SS-A+SS-B BIOCHIPs |
human |
287 | IFA | cell nuclei (ANA) EUROPattern cell nuclei (ANA) |
HEp-20-10 cells liver (2 BIOCHIPs per field) |
human monkey |
288 | IFA | cell nuclei (ANA global test) |
HEp-20-10 cells liver (2 BIOCHIPs per field) |
human monkey |
289 | IFA | EUROPLUS ANA Mosaic 10A cell nuclei (ANA) SS-A + SS-B |
2 BIOCHIPs per field: HEp-20-10 cells SS-A+SS-B BIOCHIPs |
human |
290 | IFA | EUROPLUS ANA Mosaic 20A cell nuclei (ANA) cell nuclei (ANA) SS-A + SS-B ribosomal P-proteins + Jo-1 |
4 BIOCHIPs per field: HEp-20-10 cells liver SS-A+SS-B BIOCHIPs rib. P-prot.+Jo-1 BIOCHIPs |
human monkey |
291 | IFA | EUROPLUS ANA Mosaic 22A cell nuclei (ANA) cell nuclei (ANA) nRNP/Sm + Sm + SS-A SS-B + Scl-70 + Jo-1 |
4 BIOCHIPs per field: HEp-20-10 cells liver nRNP/Sm+Sm+SS-A BIOCHIPs SS-B+Scl-70+Jo-1 BIOCHIPs |
human monkey |
292 | IFA | cell nuclei (ANA) cell nuclei (ANA) |
HEp-20-10 cells liver (2 BIOCHIPs per field) |
human rat |
293 | IFA | cell nuclei (ANA) | HEp-2 cells | human |
294 | IFA | cell nuclei (ANA) EUROPattern |
HEp-2 cells | human |
295 | IFA | cell nuclei (ANA) | HEp-20-10 cells | human |
296 | IFA | cell nuclei (ANA) EUROPattern |
HEp-20-10 cells | human |
297 | ELISA | histones | antigen-coated microplate wells |
native, highly purified histones, bovine thymus |
298 | IFA | antibodies against cell nuclei (ANA control), homogeneous pattern |
||
299 | IFA | test performance control (ANA homogeneous, IgG) |
||
300 | IFA | antibodies against cell nuclei (ANA control), homogeneous pattern, control serum with indication of titer, reference serum W 1064 (66/233) |
||
301 | IFA | antibodies against cell nuclei, aliquots from positive control for ANA diagnostics (20 different fluorescence patterns) |
||
302 | IFA | antibodies against cell nuclei (ANA control), homogeneous pattern, control serum with indication of titer |
||
303 | IFA | antibodies against cell nuclei (ANA control), homogeneous pattern, for EUROPattern |
||
304 | ELISA | double-stranded DNA (dsDNA) |
antigen-coated microplate wells |
highly purified genomic double-stranded |
305 | RIA | double-stranded DNA (dsDNA) precipitation |
labelled antigen | plasmid DNA |
306 | IFA | antibodies against dsDNA (dsDNA ab control) |
||
307 | IFA | dsDNA | flagellates | Crithidia luciliae |
308 | IFA | dsDNA EUROPattern |
flagellates | Crithidia luciliae |
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