Products - Autoimmune - Rheumatology -
Many of the medium and small vessel vasculitis share an autoimmune etiology. Consider some examples:
All these are associated with ANCA (antineutrophil cytoplasmic antibodies). These antibodies attack antigens found in the cytoplasmic granules of neutrophils and monocytes and serve as an important serological marker for autoimmune (ANCA-associated) vasculitis.
Patients with glomerulonephritis in which antibodies are formed against the glomerular basement membranes, also turn out positive for serum ANCAs. Hence its important to double check the patients positive for anti-GBM antibodies, to look for any associated antineutrophil cytoplasmic antibodies indicative of autoimmune vasculitis.
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wdt_ID | Method | Parameter | Substrate | Species/ Antigen |
---|---|---|---|---|
144 | IFA | antibodies against granulocyte cytoplasm, cytoplasmic pattern (cANCA control, PR3 ab control) |
||
145 | IFA | cytoplasm of granulocytes (cANCA, pANCA), nuclei of granulocytes (GS-ANA) |
granulocytes, ethanol-fixed |
human |
146 | IFA | cytoplasm of granulocytes (cANCA, pANCA), nuclei of granulocytes (GS-ANA) EUROPattern |
granulocytes, ethanol-fixed |
human |
147 | IFA | antibodies against granulocyte cytoplasm, aliquots from positive control for ANCA diagnostics (10 different fluorescence patterns) |
||
148 | ELISA | ANCA Profile (proteinase 3, MPO, elastase, cathepsin G, BPI, lactoferrin separately) |
antigen-coated microplate wells |
native, human neutrophil granulocytes recombinant, human c-DNA expressed in human cell line |
149 | EUROLINE | myeloperoxidase (MPO) proteinase 3 (PR3) |
EUROLINE | |
150 | EUROLINE | positive control serum: IgG, human, 100x concentrated for DL 1200-X G |
||
151 | IFA | antibodies against granulocyte cytoplasm, cytoplasmic pattern (cANCA control, PR3 ab control), control serum with indication of titer |
||
152 | EUROLINE | myeloperoxidase (MPO) proteinase 3 (PR3) glomerular basement membrane (GBM) |
EUROLINE | |
153 | IFA | granulocytes (cANCA, pANCA) |
granulocytes, formaldehyde-fixed |
human |
154 | IFA | granulocytes (cANCA, pANCA) EUROPattern |
granulocytes, formaldehyde-fixed |
human |
155 | ChLIA | control set Proteinase 3 (PR3) |
||
156 | ChLIA | proteinase 3 (PR3) | ||
157 | IFA | Granulocyte Mosaic 13 EUROPattern cANCA, pANCA, GS-ANA, EUROPattern cell nuclei (ANA), cANCA, pANCA cANCA, pANCA, EUROPattern |
3 BIOCHIPs per field: granulocytes (EOH) HEp-2+granulocytes (EOH) granulocytes (HCHO) |
human human human |
158 | IFA | Granulocyte Mosaic 13 cANCA, pANCA, GS-ANA cell nuclei (ANA), cANCA, pANCA cANCA, pANCA |
3 BIOCHIPs per field: granulocytes (EOH) HEp-2+granulocytes (EOH) granulocytes (HCHO) |
human human human |
159 | IFA | Granulocyte Mosaic 15 EUROPattern cANCA, pANCA, GS-ANA, EUROPattern cell nuclei (ANA), cANCA, pANCA |
2 BIOCHIPs per field: granulocytes (EOH) HEp-2+granulocytes (EOH) |
human human |
160 | IFA | Granulocyte Mosaic 15 cANCA, pANCA, GS-ANA cell nuclei (ANA), cANCA, pANCA |
2 BIOCHIPs per field: granulocytes (EOH) HEp-2+granulocytes (EOH) |
human human |
161 | IFA | Granulocyte Mosaic 17 cANCA, pANCA, GS-ANA cANCA, pANCA cANCA, pANCA cell nuclei (ANA), cANCA, pANCA |
4 BIOCHIPs per field: granulocytes (EOH) granulocytes (HCHO) granulocytes (MOH) HEp-2+granulocytes (EOH) |
human human human human |
162 | IFA | Granulocyte Mosaic 2 EUROPattern cANCA, pANCA, GS-ANA, EUROPattern cANCA, pANCA, EUROPattern |
2 BIOCHIPs per field: granulocytes (EOH) granulocytes (HCHO) |
human human |
163 | IFA | Granulocyte Mosaic 2 cANCA, pANCA, GS-ANA cANCA, pANCA |
2 BIOCHIPs per field: granulocytes (EOH) granulocytes (HCHO) |
human human |
164 | ELISA | cANCA: proteinase 3 (PR3-hn-hr) |
antigen-coated microplate wells |
hn: native, human neutrophil granulocytes hr: recombinant, human c-DNA expressed in human cell line |
165 | IFA | EUROPLUS Granulocyte Mosaic 20 cANCA, pANCA, GS-ANA pANCA: myeloperoxidase (MPO) cANCA: proteinase 3 (PR3) |
3 BIOCHIPs per field: granulocytes (EOH) MPO BIOCHIPs PR3 BIOCHIPs |
human |
166 | IFA | EUROPLUS Granulocyte Mosaic 22 cANCA, pANCA, GS-ANA cANCA, pANCA pANCA: myeloperoxidase (MPO) cANCA: proteinase 3 (PR3) |
4 BIOCHIPs per field: granulocytes (EOH) granulocytes (HCHO) MPO BIOCHIPs PR3 BIOCHIPs |
human human |
167 | IFA | EUROPLUS Granulocyte Mosaic 22 EUROPattern cANCA, pANCA, GS-ANA, EUROPattern cANCA, pANCA, EUROPattern pANCA: myeloperoxidase (MPO), EUROPattern cANCA: proteinase 3 (PR3), EUROPattern |
4 BIOCHIPs per field: granulocytes (EOH) granulocytes (HCHO) MPO BIOCHIPs PR3 BIOCHIPs |
human human |
168 | IFA | EUROPLUS Granulocyte Mosaic 25 cANCA, pANCA, GS-ANA cell nuclei (ANA), cANCA, pANCA cANCA, pANCA glomerular basement membrane (GBM) pANCA: myeloperoxidase (MPO) cANCA: proteinase 3 (PR3) |
6 BIOCHIPs per field: granulocytes (EOH) HEp-2+granulocytes (EOH) granulocytes (HCHO) GBM BIOCHIPs MPO BIOCHIPs PR3 BIOCHIPs |
human human human |
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