Infertility may be caused by antibodies against various tissues and cells that are essential for reproduction. In 20% of cases of immunologically mediated fertility disorders, anti-spermatozoa antibodies are detected (autoantibodies in men or alloantibodies in women). These antibodies primarily impair the mobility of the spermatozoa through surface binding and through agglutination processes.
Antibodies against ovarian antigens can be detected in women with primary ovarian insufficiency and after repeated in vitro fertilization. The autoantibodies are directed against various ovarian structures and inhibit the maturation of the egg and its interaction with spermatozoa. Target antigens are steroid-producing enzymes – especially in the theca interna cells – and the zona pellucida.
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|549||IFA||Infertility Mosaic 7
5 BIOCHIPs per field:
|550||IFA|| antibodies against ovary: theca cells
(ovary ab control)
|552||IFA||antibodies against testis: Leydig cells
(testis ab control)
|553||IFA||antibodies against spermatozoa|