Products - Autoimmune - Hepatology - Primary sclerosing cholangitis

Primary sclerosing cholangitis

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Information

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with progressive destruction of the bile ducts. PSC can exhibit autoantibodies against granulocytes (pANCA) in the serological test; the main target antigen is DNA-bound lactoferrin.

Diagnostic Guidelines

PSC has a prevalence of approximately 8 to 14 patients in 100,000 people. Men are more frequently affected by the disease than women (60-80%) and the disease is mainly diagnosed at the age of 30 to 60. PSC occurs more often in patients with chronic inflammatory bowel diseases (85 to 90% ulcerative colitis and 10 to 15% Crohn’s disease). Cholangiography is the most important method to achieve a reliable diagnosis. Although a number of autoantibodies occur in PSC, it is not a typical autoimmune disease. However, it may be associated with autoimmune phenomena in childhood, including high titers of autoantibodies (e.g. ANA, ANCA and ASMA). In suspected cases of overlap syndrome with autoimmune hepatitis or primary biliary cholangitis (up to 10% of cases), serological antibody tests may provide additional diagnostic information.

Primary sclerosing cholangitis products

For Research Use Only. Not For Use In Diagnostic Procedures.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
439 IFA antibodies against granulocyte cytoplasm,
cytoplasmic pattern (cANCA control, PR3 ab control)
440 IFA cytoplasm of granulocytes (cANCA,
pANCA), nuclei of granulocytes (GS-ANA)
granulocytes,
ethanol-fixed
human
441 IFA cytoplasm of granulocytes (cANCA,
pANCA), nuclei of granulocytes (GS-ANA)
EUROPattern
granulocytes,
ethanol-fixed
human
442 IFA antibodies against granulocyte cytoplasm,
aliquots from positive control for ANCA diagnostics
(10 different fluorescence patterns)
443 ELISA ANCA Profile (proteinase 3, MPO, elastase,
cathepsin G, BPI, lactoferrin separately)
antigen-coated
microplate wells
native, human
neutrophil granulocytes
recombinant, human c-DNA
expressed in human cell line
445 EUROLINE myeloperoxidase (MPO)
proteinase 3 (PR3)
EUROLINE
446 EUROLINE positive control serum: IgG, human, 100x concentrated
for DL 1200-X G
447 IFA antibodies against granulocyte cytoplasm, cytoplasmic pattern
(cANCA control, PR3 ab control), control serum with indication of titer
448 EUROLINE myeloperoxidase (MPO)
proteinase 3 (PR3)
glomerular basement membrane (GBM)
EUROLINE
449 IFA granulocytes
(cANCA, pANCA)
granulocytes,
formaldehyde-fixed
human
450 IFA granulocytes
(cANCA, pANCA)
EUROPattern
granulocytes,
formaldehyde-fixed
human
451 ChLIA control set
Proteinase 3 (PR3)
452 ChLIA proteinase 3 (PR3)
453 IFA Granulocyte Mosaic 13 EUROPattern
cANCA, pANCA, GS-ANA, EUROPattern
cell nuclei (ANA), cANCA, pANCA
cANCA, pANCA, EUROPattern
3 BIOCHIPs per field:
granulocytes (EOH)
HEp-2+granulocytes (EOH)
granulocytes (HCHO)
human
human
human
454 IFA Granulocyte Mosaic 13
cANCA, pANCA, GS-ANA
cell nuclei (ANA), cANCA, pANCA
cANCA, pANCA
3 BIOCHIPs per field:
granulocytes (EOH)
HEp-2+granulocytes (EOH)
granulocytes (HCHO)
human
human
human
455 IFA Granulocyte Mosaic 15 EUROPattern
cANCA, pANCA, GS-ANA, EUROPattern
cell nuclei (ANA), cANCA, pANCA
2 BIOCHIPs per field:
granulocytes (EOH)
HEp-2+granulocytes (EOH)
human
human
456 IFA Granulocyte Mosaic 15
cANCA, pANCA, GS-ANA
cell nuclei (ANA), cANCA, pANCA
2 BIOCHIPs per field:
granulocytes (EOH)
HEp-2+granulocytes (EOH)
human
human
457 IFA Granulocyte Mosaic 17
cANCA, pANCA, GS-ANA
cANCA, pANCA
cANCA, pANCA
cell nuclei (ANA), cANCA, pANCA
4 BIOCHIPs per field:
granulocytes (EOH)
granulocytes (HCHO)
granulocytes (MOH)
HEp-2+granulocytes (EOH)
human
human
human
human
458 IFA Granulocyte Mosaic 2 EUROPattern
cANCA, pANCA, GS-ANA, EUROPattern
cANCA, pANCA, EUROPattern
2 BIOCHIPs per field:
granulocytes (EOH)
granulocytes (HCHO)
human
human
459 IFA Granulocyte Mosaic 2
cANCA, pANCA, GS-ANA
cANCA, pANCA
2 BIOCHIPs per field:
granulocytes (EOH)
granulocytes (HCHO)
human
human
460 ELISA cANCA:
proteinase 3
(PR3-hn-hr)
antigen-coated
microplate wells
microplate wells
hn: native, human
neutrophil granulocytes
hr: recombinant, human c-DNA
expressed in human cell line
461 IFA EUROPLUS Granulocyte Mosaic 20
cANCA, pANCA, GS-ANA
pANCA: myeloperoxidase (MPO)
cANCA: proteinase 3 (PR3)
3 BIOCHIPs per field:
granulocytes (EOH)
MPO BIOCHIPs
PR3 BIOCHIPs
human
462 IFA EUROPLUS Granulocyte Mosaic 22
cANCA, pANCA, GS-ANA
cANCA, pANCA
pANCA: myeloperoxidase (MPO)
cANCA: proteinase 3 (PR3)
4 BIOCHIPs per field:
granulocytes (EOH)
granulocytes (HCHO)
MPO BIOCHIPs
PR3 BIOCHIPs
human
human
463 IFA EUROPLUS Granulocyte Mosaic 22
EUROPattern
cANCA, pANCA, GS-ANA, EUROPattern
cANCA, pANCA, EUROPattern
pANCA: myeloperoxidase (MPO), EUROPattern
cANCA: proteinase 3 (PR3), EUROPattern
4 BIOCHIPs per field:
granulocytes (EOH)
granulocytes (HCHO)
MPO BIOCHIPs
PR3 BIOCHIPs
human
human
464 IFA EUROPLUS Granulocyte Mosaic 25
cANCA, pANCA, GS-ANA
cell nuclei (ANA), cANCA, pANCA
cANCA, pANCA
glomerular basement membrane (GBM)
pANCA: myeloperoxidase (MPO)
cANCA: proteinase 3 (PR3)
6 BIOCHIPs per field:
granulocytes (EOH)
HEp-2+granulocytes (EOH)
granulocytes (HCHO)
GBM BIOCHIPs
MPO BIOCHIPs
PR3 BIOCHIPs
human
human
human
Method Parameter Substrate Species/ Antigen
Contact our Autoimmune Product Team for further details and information
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