Highly specific (> 98 %)1
Highly specific (> 98 %)1
Aids in the diagnosis of Rheumatoid arthritis
Reliable results due to original CCP2 antigen
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovial inflammation, progressive joint destruction, and functional impairment. Approximately 0.5–1% of the global population is affected, with women more frequently diagnosed than men.2
Autoantibodies play a central role in RA pathogenesis and may be detectable years before clinical symptoms develop. Many RA patients (approx. 70 %) produce autoantibodies against citrullinated peptides (ACPA).3 Consequently, immune complexes are formed, and inflammation of the joints progresses.
During the transition from undifferentiated arthritis to RA, ACPA levels increase and remain high.4 ACPA have a high predictive value for the development of RA and their detection supports the early recognition of the disease.
Euroimmun offers a comprehensive portfolio of solid-phase immunoassays for the detection of RA-associated autoantibodies, supporting early detection and risk stratification.
ACPA are highly specific for RA and their determination has been incorporated into the 2010 classification criteria of the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR), where antibody titers contribute significantly to diagnostic scoring.5 ACPA are determined in parallel to rheumatoid factors (RF). According to the scoring system of the ACR/EULAR classification, a high ACPA or RF titer carries more weight for the classification of RA than a lower titer. Laboratory findings such as an increased erythrocyte sedimentation rate, increased C-reactive protein and the presence of RF and/or ACPA are indicative of RA.5
Autoantibodies against CCP can be determined using ELISA and ChLIA. For the detection of ACPA, the second-generation CCP antigen (CCP2) is considered the gold standard.6,1 Test systems based on this antigen provide the highest sensitivity (80%, with a specificity of 98%).1 Antibodies against CCP are mainly IgG class antibodies and are significantly more specific than RF, with a similar sensitivity.7
References
For in vitro diagnostic use.
2026 Euroimmun US
Privacy Policy | Website Terms and Conditions | Cookie Notice and Settings | Consent Preferences | Sitemap