Complete testing portfolio
All three critical markers (hGH, IGF-1, IGFBP-3)
Complete testing portfolio
All three critical markers (hGH, IGF-1, IGFBP-3)
Technical superiority
No pegvisomant interference, detects only 22 kDa hGH
Extensive global reference ranges
Adult and pediatric reference ranges stratified by Tanner stages3-5
Clinical compliance
WHO-calibrated, consensus guideline adherent
Growth hormone (GH) plays a critical role in regulating growth, metabolism, and body composition. Produced by the anterior pituitary gland of the brain, its secretion is highly regulated through feedback mechanisms in response to sleep, exercise, stress, nutrition, and growth hormone concentration itself.1 Growth hormone acts directly on nearly every tissue and organ in the body, and indirectly via the actions of another hormone, Insulin-like Growth Factor-1 (IGF-1), which is secreted by cells of the liver in response to growth hormone binding its respective surface receptors.1 Both growth hormone and insulin-like growth factor-1 work together to induce growth of peripheral tissues, most notably, bone, muscle, and cartilage in the years of adolescence.1
Disorders of the growth hormone axis, such as acromegaly, gigantism, and GH deficiency in childhood, adolescence, and adulthood, are commonly determined by measuring levels of growth hormone during a growth hormone stimulation or growth hormone suppression test, in conjunction with measuring Insulin-like Growth Factor-1 (IGF-1) and/or Insulin-like Growth Factor Binding Protein-3 (IGFBP-3). These hormones play an important role in both the diagnosis of disease and the monitoring of treatment. Several consensus statements published over the last decade have established how to utilize and interpret these parameters in clinical practice.2
Euroimmun has a comprehensive growth laboratory profile, including growth hormone, insulin-like growth factor-1, and insulin-like growth factor binding protein-3, to support the identification and evaluation of growth disorders, pituitary function, and other endocrine disorders.
With the largest reference ranges published for both our IGF-1 and IGFBP-3 assays and full integration with random-access ChLIA platforms (e.g. IDS-iSYS, IDS-i10, etc.), you can be sure your testing both is reliable and time-efficient. We even offer the SDSpeed Calc software to aid clinicians in determining the SD-score from IGF-1 and IGFBP-3 measurements.
References
For in vitro diagnostic use.
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