HLA-Cw6 Direct

Information

HLA-C*06 alleles are the genetic component for the predisposition to the autoimmune reactions that result in psoriasis. Recent total-genome association studies have confirmed that of all gene sites HLA-C shows the highest association with psoriasis, and HLA-C*06 can be considered by far the most powerful genetic marker for the disease. The determination of HLA-C*06 is of great significance since the presence of the HLA-Cw6 antigen is associated in particular with type 1 psoriasis vulgaris (OR 16.0) and psoriasis guttata (OR 33.6), but only is comparatively weakly associated (OR 2.6) with type 2 psoriasis vulgaris. Type 1 psoriasis vulgaris has a more severe course than type 2 psoriasis vulgaris.