Products - Molecular genetic - Molecular genetics - APO-E

APOE

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Disease information

The APOE gene encodes for apolipoprotein E, a component of lipoproteins which are vehicles for the transport of cholesterol (fat) in blood. Polymorphisms in this gene are associated with Alzheimer’s disease. Two important allele types associated with the disease are e4 and e2. The difference is that where e4 is associated with a higher risk of developing Alzheimer’s, e2 lowers the risk.

People with Alzheimer’s disease have the allele e4 3 times more commonly than normal individuals. The allele decides the risk and age of disease onset especially in families where late-onset Alzheimer’s disease has occurred. It is 20% and 84 years for non-e4 carriers, 47% and 76 years for heterozygous carriers and 91% and 68 years for homozygous carriers of the e4 allele. Moreover, the allele also provides pharmacogenetic targets for the development of new Alzheimer medications.

Diagnostic Guidelines

The EUROArray APOE Direct assay is designed for molecular determination of different APOE alleles including e2, e3 and e4 especially with respect to early recognition of late onset sporadic Alzheimer’s disease. It also helps to assess other conditions such as type 3 hyperlipoproteinemia, atherosclerosis and vascular diseases (coronary heart disease and stroke) as these are also associated with APOE alleles.

The test is simple and efficient as it is employed directly on blood samples eliminating the need for time consuming DNA isolation.

APOE products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter
768 EUROArray EUROArray APOE
Method Parameter
Contact our Molecular Genetic Product Team for further details and information

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