HLA-B27 is the second human leukocyte antigen in our discussion. It is associated with autoimmune arthropathy mainly ankylosing spondylitis (characterized by fusion of the joint surfaces and immobility). The association can be gauged by the fact that 3 to 6 percent of HLA-B27 carriers develop ankylosing spondylitis and about 90 percent people who develop ankylosing spondylitis have HLA-B27.
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