Products - Molecular genetic - Molecular genetics - HLA-B57:01

HLA-B57:01

Contact our Molecular Genetic Product Team for further details and information

Disease information

Human leukocyte antigens (HLA) are surface molecules present on antigen presenting cells through which they present antigenic peptides to the helper and cytotoxic T-cells (to bring about the immune response). Of them HLA-B57:01 is associated with HIV and testing for it is done to prevent any hypersensitivity reaction when treating the HIV with abacavir. About 8 percent of the people carry this HLA allele. And 8 to 61 percent of the HIV patients who carry this allele and are treated with abacavir develop hypersensitivity reactions within six weeks. The manifestations include:

  • Fever
  • Exanthema
  • Pruritis
  • GI and respiratory problems
  • Joint pain
  • Liver and kidney problems

These can progress up to death especially with re-exposure. Hence this thing can’t be stressed enough that people with HIV should be tested for HLA-B57:01 prior to starting them on abacavir.

Diagnostic Guidelines

EUROIMMUN offers EUROArray HLA-B57:01 Direct for quick and simple determination of these alleles in genomic DNA. All currently known HLA-B57:01 alleles are detected in a single test and the results obtained are automatically evaluated by EUROArrayScan software. The good thing about this test is that it enables direct testing on blood without the need to isolate DNA, which significantly reduces both the time required and the cost of the test.

HLA-B57:01 products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter
768 EUROArray EUROArray HLA-B57:01
Method Parameter
For product information, please contact the EUROIMMUN Sales Team

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