Products - Molecular genetic - Molecular infection diagnostics - HSV-1/2

HSV-1/2

Contact our Molecular Genetic Product Team for further details and information

Disease information

Herpes simplex virus 1 (HSV-1) and herpes simplex virus 2 (HSV-2) are worldwide distributed, human pathogenic viruses from the family Herpesviridae. If the lips and facial region are affected, HSV-1 is usually the pathogenic agent while genital infections can be caused by either virus type. In 20% to 30% of cases they are caused by HSV-1.

In primary infections the virus penetrates the mucosal cells, multiplies and is released in ulcers or inflammatory skin blisters. Infections persist lifelong, alternating between asymptomatic and acute phases. In adults, HSV infection may cause encephalitis or meningitis and, in immunodeficient patients, also disseminated infections which may cause lesions at different locations in the skin, or enter into the central nervous system. Alongside mild courses, infections in newborns may also lead to neonatal herpes encephalitis or to disseminated forms. Infections in foetuses often result in intrauterine death, malformations or preterm birth.

Diagnostic Guidelines

The EURORealTime HSV-1/2 test allows highly specific and sensitive detection of HSV-1 and HSV-2 as well as quantification of viral DNA by means of real-time polymerase chain reaction (real-time PCR). The test system allows for the direct detection of HSV-1 and HSV-2 within the framework of diagnostics of sexually transmitted infections and infections causing herpes simplex encephalitis. The molecular genetic detection by means of EURORealTime HSV-1/2 PCR is especially suited for early diagnostics of HSV-1 and -2 infections as well as for differentiation of both types and is significantly faster, compared to detection in culture.

The analysis of raw data, evaluation, creation of reports and electronic archiving can be performed fully automatically by means of the EURORealTime Analysis Software. The standard curves used for the automatic quantification of the viral load can be stored and reused in later runs, if required. Moreover, the software offers convenient guidance through the entire workflow and thus helps to avoid errors. The direct detection of HSV-1 and -2 by means of EURORealTime HSV-1/2 PCR and EURORealTime Analysis Software is extremely easy to perform – no in-depth molecular biological knowledge is required.

HSV-1/2 products

The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
636 PCR EURORealTime HSV-1/2
637 IFA antibodies against Herpes simplex virus 1 (HSV-1)
IgG positive control
638 IFA antibodies against Herpes simplex virus 1 (HSV-1)
IgM positive control
639 IFA Herpes simplex virus 1
(HSV-1)
infected cells EU 38
640 IFA HSV-1/HSV-2
negative control
641 WESTERNBLOT antibodies against Herpes simplex virus (HSV)
IgG positive control
642 IFA BIOCHIP Mosaic
HSV-1/HSV-2
2 BIOCHIPs per field:
infected cells
EU 38
643 ELISA CSQ pair of controls
anti-HSV-1/2 Pool (IgG)
644 ELISA Herpes simplex virus
(HSV-1/2 Pool)
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
645 ELISA Herpes simplex virus
(HSV-1/2 Pool)
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
646 ELISA Herpes simplex virus
(HSV-1/2 Pool)
antibody determination in CSF
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
647 ELISA Herpes simplex virus
(HSV-1/2 Pool)
incl. IgG/RF absorbent
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
648 WESTERNBLOT EUROLINE-WB
Herpes simplex virus 1 (HSV-1)
plus HSV-2 type-specific
glycoprotein G2
Westernblot whole antigen, SDS extract of HSV-1
plus purified gG2
649 ELISA Herpes simplex virus 1 (HSV-1)
incl. IgG/RF absorbent
antigen-coated
microplate wells
native
glycoprotein C1
650 ELISA Herpes simplex virus 1
(HSV-1)
antigen-coated
microplate wells
recombinant
glycoprotein C1
651 IFA antibodies against Herpes simplex virus 2 (HSV-2)
IgG positive control
652 IFA antibodies against Herpes simplex virus 2 (HSV-2)
IgM positive control
653 IFA Herpes simplex virus 2
(HSV-2)
infected cells EU 38
654 ELISA Herpes simplex virus 2 (HSV-2)
incl. IgG/RF absorbent
antigen-coated
microplate wells
recombinant
glycoprotein G2
655 ELISA Herpes simplex virus 2
(HSV-2)
antigen-coated
microplate wells
recombinant
glycoprotein G2
656 IFA antibodies against HHV-6
IgG positive control
657 IFA antibodies against HHV-6
IgM positive control
658 IFA HHV-6 infected cells EU 30
659 IFA HHV-6 EUROPattern infected cells EU 30
660 IFA HHV-6
negative control
Method Parameter Substrate Species/ Antigen
For product information, please contact the EUROIMMUN Sales Team

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