Products - Molecular genetic - Molecular - Herpesviruses (HSV-1/2)

Herpesviruses (HSV-1/2)

Contact our Molecular Genetic Product Team for further details and information

Information

Herpes simplex virus types -1 and -2 (HSV-2 and HSV-2) and varicella zoster virus (VZV) are human pathogenic viruses from the Herpesviridae family. The closely related human pathogenic virus species HSV-1 and HSV-2 from the herpesviridae family are the causative agents of different diseases.

Diagnostic Guidelines

The EUROArray HSV-1/-2 VZV provides direct detection and differentiation of HSV-1, HSV-2 and VZV from skin, buccal and genital swabs. It allows fast and easy differentiation of the pathogens (e.g. eczema herpeticum vs. varicella or herpes simplex vs. herpes zoster). Moreover, the assay allows one to differentiate herpes infections from other dermatoses with similar manifestations (e.g. fungal infections, fixed drug eruption, contact dermatitis) Data analysis, data interpretation and archiving are done completely automated by means of the EUROArrayScan software.

The EURORealTime HSV-1/2 provides detection ad quantification of HSV-1 and HSV-2 DNA by means of real-time PCR from swabs, CSF and EDTA plasma. Data analysis, evaluation, and archiving of the test results can be performed fully automatically using the EURORealTime Analysis software. Standard curves for automated quantification of the viral load can be stored in the software and re-used.
Alongside the molecular assays, EUROIMMUN also offers a wide range of products for the detection of antibodies against herpes viruses.

The infections can be asymptomatic, mild, or severe. The most common manifestations are herpes labialis (lip herpes) and herpes genitalis, also rarely herpes encephalitis or herpes neonatorum in severe cases. In primary infections the virus penetrates the mucosal cells, multiplies and is released in ulcers or inflammatory skin blisters. Infections persist lifelong, alternating between asymptomatic phases and acute infectious outbreaks. Primary VZV infections manifest as varicella (chickenpox). They are transmitted via virus-containing blister fluid, conjunctival liquid and saliva and are a very infectious children’s disease. After first manifestation the virus establishes latency in sensory nerve cells and can subsequently reactivate to cause herpes zoster (shingles) as second manifestation. Typical symptoms are painful and/or itching dermatomal exanthema, pains and sensory disorders. Asymptomatic courses have also been described. In severe cases, complications such as pneumonia, hepatitis or post-zoster neuralgia can occur.

Herpesviruses (HSV-1/2) products

For Research Use Only. Not For Use In Diagnostic Procedures.
The individual product regulatory statements may vary, please refer to the instructions for use for more information.

wdt_ID Method Parameter Substrate Species/ Antigen
636 PCR EURORealTime HSV-1/2
637 IFA antibodies against Herpes simplex virus 1 (HSV-1)
IgG positive control
638 IFA antibodies against Herpes simplex virus 1 (HSV-1)
IgM positive control
639 IFA Herpes simplex virus 1
(HSV-1)
infected cells EU 38
640 IFA HSV-1/HSV-2
negative control
641 WESTERNBLOT antibodies against Herpes simplex virus (HSV)
IgG positive control
642 IFA BIOCHIP Mosaic
HSV-1/HSV-2
2 BIOCHIPs per field:
infected cells
EU 38
643 ELISA CSQ pair of controls
anti-HSV-1/2 Pool (IgG)
644 ELISA Herpes simplex virus
(HSV-1/2 Pool)
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
645 ELISA Herpes simplex virus
(HSV-1/2 Pool)
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
646 ELISA Herpes simplex virus
(HSV-1/2 Pool)
antibody determination in CSF
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
647 ELISA Herpes simplex virus
(HSV-1/2 Pool)
incl. IgG/RF absorbent
antigen-coated
microplate wells
native antigens
from HSV-1 and HSV-2
648 WESTERNBLOT EUROLINE-WB
Herpes simplex virus 1 (HSV-1)
plus HSV-2 type-specific
glycoprotein G2
Westernblot whole antigen, SDS extract of HSV-1
plus purified gG2
649 ELISA Herpes simplex virus 1 (HSV-1)
incl. IgG/RF absorbent
antigen-coated
microplate wells
native
glycoprotein C1
650 ELISA Herpes simplex virus 1
(HSV-1)
antigen-coated
microplate wells
recombinant
glycoprotein C1
651 IFA antibodies against Herpes simplex virus 2 (HSV-2)
IgG positive control
652 IFA antibodies against Herpes simplex virus 2 (HSV-2)
IgM positive control
653 IFA Herpes simplex virus 2
(HSV-2)
infected cells EU 38
654 ELISA Herpes simplex virus 2 (HSV-2)
incl. IgG/RF absorbent
antigen-coated
microplate wells
recombinant
glycoprotein G2
655 ELISA Herpes simplex virus 2
(HSV-2)
antigen-coated
microplate wells
recombinant
glycoprotein G2
656 IFA antibodies against HHV-6
IgG positive control
657 IFA antibodies against HHV-6
IgM positive control
658 IFA HHV-6 infected cells EU 30
659 IFA HHV-6 EUROPattern infected cells EU 30
660 IFA HHV-6
negative control
Method Parameter Substrate Species/ Antigen
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Contact our Molecular Genetic Product Team for further details and information
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